Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment.
Aberrant intra- and inter-network connectivity architectures in Alzheimer's disease and mild cognitive impairment.
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阿尔茨海默病和轻度认知障碍中异常的网络内和网络间连接架构
DOI：
10.1038/srep14824
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发表时间：
2015-10-06
影响因子：
4.6
通讯作者：
Jiang T
中科院分区：
文献类型：
--
作者：
Wang P;Zhou B;Yao H;Zhan Y;Zhang Z;Cui Y;Xu K;Ma J;Wang L;An N;Zhang X;Liu Y;Jiang T
阿尔茨海默病（AD）患者和高危轻度认知障碍患者越来越多地被认为具有功能障碍综合征。基于神经成像技术的大规模网络研究可能为阿尔茨海默病的病理生理学提供额外的见解。本研究的目的是评估受损的网络功能连接与疾病的进展。为此，我们在35名AD患者和27名轻度认知障碍（MCI）患者中，与27名正常认知受试者相比，基于先前定义明确的由五个关键功能系统(默认模式网络（DMN）、背侧注意网络（DAN）、控制网络（CON）、突出网络（SAL）、感觉运动网络（SMN）组成的大脑区域，探索了功能连接的变化。基于三个层次的分析，我们发现AD的网络内部和网络之间的连通性受损。重要的是，感觉运动和注意功能之间的相互作用首先在MCI阶段受到攻击，然后扩展到AD个体的关键功能系统。在所有患者组中，较低的认知能力（较低的MMSE评分）与更大程度的网络内和网络间连通性降低显著相关。这些特征表明，异常的网络内部和网络之间的功能障碍可能是阿尔茨海默病进展的潜在生物标志物或预测因素，并为阿尔茨海默病的病理生理学提供了新的见解。
Alzheimer’s disease (AD) patients and those with high-risk mild cognitive impairment are increasingly considered to have dysfunction syndromes. Large-scale network studies based on neuroimaging techniques may provide additional insight into AD pathophysiology. The aim of the present study is to evaluate the impaired network functional connectivity with the disease progression. For this purpose, we explored altered functional connectivities based on previously well-defined brain areas that comprise the five key functional systems [the default mode network (DMN), dorsal attention network (DAN), control network (CON), salience network (SAL), sensorimotor network (SMN)] in 35 with AD and 27 with mild cognitive impairment (MCI) subjects, compared with 27 normal cognitive subjects. Based on three levels of analysis, we found that intra- and inter-network connectivity were impaired in AD. Importantly, the interaction between the sensorimotor and attention functions was first attacked at the MCI stage and then extended to the key functional systems in the AD individuals. Lower cognitive ability (lower MMSE scores) was significantly associated with greater reductions in intra- and inter-network connectivity across all patient groups. These profiles indicate that aberrant intra- and inter-network dysfunctions might be potential biomarkers or predictors of AD progression and provide new insight into AD pathophysiology.