Ghrelin and leptin modulate immunity and liver function in overweight children
Ghrelin and leptin modulate immunity and liver function in overweight children
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DOI：
10.1111/j.1442-200x.2008.02647.x
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发表时间：
2009-02-01
影响因子：
1.4
通讯作者：
Matsuishi, Toyojiro
中科院分区：
文献类型：
--
作者：
Okamatsu, Yuki;Matsuda, Kentaro;Matsuishi, Toyojiro
肥胖症的日益流行代表了日益严重的全球公共卫生问题。目前认为脂肪细胞因子和低度全身性炎症的相互作用在肥胖以及相关慢性疾病（包括支气管哮喘、肥胖相关肝病和2型糖尿病）的发展中是重要的。本研究的目的是调查超重儿童的代谢，激素，免疫和炎症因素，并进一步阐明肥胖相关的激素和细胞因子可能的免疫调节作用。49名青春期前超重儿童和49名年龄匹配的正常体重对照，无基础疾病。血浆ghrelin、血清瘦素、细胞因子水平检测白细胞介素4、白细胞介素10、白细胞介素12、白细胞介素13、C反应蛋白、免疫球蛋白和胰岛素，并进行肝功能检查，以更好地了解它们在肥胖背景下的状况。肥胖儿童的血清IgG、IgA和IgE水平显著高于非肥胖儿童（P = 0.038，0.0043，0.0034），IgM水平则相反（P = 0.025）。在超重儿童中，假定非酒精性脂肪肝的发病率为28.6%。在超重儿童中，血清瘦素水平与肝功能指标（天冬氨酸转氨酶/丙氨酸转氨酶比值）和血清胰岛素水平相关。某些免疫球蛋白水平升高与血浆ghrelin水平和肝功能指标显著相关，可能食欲调节激素对体液免疫和肝功能均有调节作用。需要更多受试者的进一步研究来阐明这种关联的确切机制。
The rising prevalence of obesity represents a growing worldwide public health problem. Interactions of adipocytokines and low-grade systemic inflammation presently are considered important in the development of obesity, as well as associated chronic disease including bronchial asthma, obesity-related liver disease and type 2 diabetes mellitus. The purpose of the present study was to investigate metabolic, hormonal, immunologic and inflammatory factors in overweight children and to further clarify possible immunomodulatory effects of obesity-related hormones and cytokines.Forty-nine prepubertal overweight children and 49 age-matched controls of normal weight without underlying disease were enrolled. Levels of plasma ghrelin and serum leptin, cytokines (interleukin [IL]-4, IL-10, IL-12, 1L-13), C-reactive protein, immunoglobulin, and insulin were measured, and liver function tests were done to better understand their status in the setting of obesity.Overweight subjects had significantly higher measures of adiposity (body mass indexI, % body fat) and had significantly higher serum levels of IgG, IgA and IgE than non-obese children (P = 0.038, 0.0043, 0.0034, respectively); the opposite was true for IgM (P = 0.025). The incidence of presumed non-alcoholic fatty liver disease was 28.6% in overweight children. In overweight children, serum leptin levels were associated with liver function index (aspartate aminotransferase/alanine aminotransferase ratio) and serum insulin levels. Some elevated immunoglobulin levels significantly correlated with plasma ghrelin levels and liver function index.It is possible that appetite-regulating hormones modulate both humoral immunity and liver function. Further studies with a larger number of subjects are needed to clarify the precise mechanisms of this association.