In vivo spin-trapping of radicals formed during halothane metabolism.
In vivo spin-trapping of radicals formed during halothane metabolism.
复制标题
氟烷代谢过程中形成的自由基的体内自旋捕获。
DOI：
10.1016/0006-2952(81)90375-0
复制
发表时间：
1981
影响因子：
5.8
通讯作者：
P. Downs
中科院分区：
文献类型：
--
作者：
J. Poyer;P. McCay;C. Weddle;P. Downs
本文所述的结果表明，在大鼠肝微粒体代谢氟烷过程中形成自由基。自由基通过自旋捕获稳定，并通过电子自旋共振光谱进行测定。体内吸入氟烷的完整动物的肝脏中也形成了氟烷依赖性自由基。
The results described in this paper demonstrate the formation of a free radical during the metabolism of halothane by rat liver microsomes. The radicals were stabilized by spin-trapping and assayed by electron spin resonance spectroscopy. A halothane-dependent free radical was also formed in the liver of intact animals exposed to halothane by inhalationin vivo.