APOBEC3G governs to ensure cellular oncogenic transformation
APOBEC3G governs to ensure cellular oncogenic transformation
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DOI：
10.1016/j.bcmd.2015.07.009
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发表时间：
2015-10-01
影响因子：
2.3
通讯作者：
Chauhan, Nalini
中科院分区：
文献类型：
--
作者：
Garg, Anuradha;Kaul, Deepak;Chauhan, Nalini
APOBEC 3G基因的致癌潜力最近被发现，揭示了APOBEC 3G对micro-RNA介导的对负责肝转移的基因的抑制的抑制作用。在这里，我们首次报道了持续的APOBEOG表达是不同组织来源的各种癌细胞所表现出的特征，以及APOBEC 3G通过与肿瘤抑制因子KLF 4的mRNA结合来抑制编码肿瘤抑制因子KLF 4的细胞基因。这种现象被细胞SP1的持续表达所掩盖，SP1确保了编码c-myc、Bmi-1、BCL-2和MDM 2的基因的过表达以及肿瘤抑制因子p53的下调，从而为致癌转化创造了有利的条件。(C)2015 Elsevier Inc. All rights reserved.
The oncogenic potential of APOBEC3G gene was recently appreciated by the finding that revealed inhibitory influence of APOBEC3G upon micro-RNA mediated repression of the gene responsible for hepatic metastasis. Here we report for the first time that sustained APOBEOG expression is the characteristic trait exhibited by various cancer cells of different tissue origins as well as APOBEC3G represses cellular gene coding for tumor suppressor KLF4 by binding to its mRNA. This phenomenon was paralleled by the sustained expression of the cellular SP1 which ensured overexpression of genes coding for c-myc, Bmi-1, BCL-2 and MDM2 coupled with downregulation of tumor suppressor p53 thereby creating a favorable situation for oncogenic transformation. (C) 2015 Elsevier Inc. All rights reserved.