Antibody responses of rats and humans to flagella-less cells and OspA protein of Borrelia burgdorferi.
Antibody responses of rats and humans to flagella-less cells and OspA protein of Borrelia burgdorferi.
复制标题
大鼠和人类对伯氏疏螺旋体无鞭毛细胞和 OspA 蛋白的抗体反应。
DOI：
10.1111/j.1749-6632.1996.tb52956.x
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发表时间：
1996
影响因子：
5.2
通讯作者：
Barbour,AG
中科院分区：
文献类型：
--
作者：
Sadziene,A;Thompson,PA;Barbour,AG
莱姆病现在是美国和欧洲最常报告的节肢动物传播疾病（综述见参考文献1）。它是由螺旋体Borrelia burgdogen'sensu Zato引起的，其分布与感染这种微生物的硬蜱的发生密切相关。在美国，莱姆病的年风险在某些社区（特别是沿着东北海岸的社区）高达0.1-1%，而在其他地区（如北方落基山脉）几乎为零。在莱姆病高度流行的郊区，人们在家中周围暴露于感染。在这种情况下，个人保护措施，如驱虫剂和特殊服装，在日常生活中是不实用或安全的。对于因居住或职业而处于高风险的人来说，安全的疫苗将是一种保护性的替代品，迄今为止，人类疫苗的重点一直是单一的重组蛋白产品。第一个候选者是OspA，B的表面暴露的外膜脂蛋白。伯多芬24只小鼠已被B保护免受注射器和蜱攻击。通过用重组OspA免疫接种burgdogen。重组OspA的人体试验正在进行中。7
Lyme disease is now the most frequently reported arthropod-borne disease in the United States and Europe (reviewed in ref. 1). It is caused by the spirochete Borrelia burgdogen'sensu Zato, and its distribution correlates closely with the occurrence of Ixodes species hard ticks that are infected with this microorganism. In the United States the annual risk of Lyme disease varies from highs of 0.1-1% in some communities, particularly those along the northeastern coast, to practically nil in other regions, such as the northern Rocky Mountains. In suburban areas that are highly endemic for Lyme disease, persons are exposed to the infection around their homes. In this situation personal protection measures, such as repellents and special clothing, are not practical or safe on a daily basis. For persons at high risk of the disease because of their residence or occupation, a safe vaccine would be an alternative for protection.The focus to date for a human vaccine has been on single recombinant protein products. The first candidate is OspA, a surface-exposed outer membrane lipoprotein of B. burgdorfen'. 24 Mice have been protected against syringe and tick challenge by B. burgdogen by immunizations with recombinant OspA. Human trials of recombinant OspA are now under way. 7