Facial-expression and gaze-selective responses in the monkey amygdala
Facial-expression and gaze-selective responses in the monkey amygdala
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DOI：
10.1016/j.cub.2007.03.040
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发表时间：
2007-05-01
期刊：
影响因子：
9.2
通讯作者：
Logothetis, Nikos K.
中科院分区：
文献类型：
--
作者：
Hoffman, Kari L.;Gothard, Katalin M.;Logothetis, Nikos K.
人类和非人类灵长类动物的社会行为都依赖于个体识别、面部表情和注视方向的专业化[1-5]。皮层和皮层下结构的广泛网络与面部处理有关，但尚不清楚面部刺激的同时发生的维度（例如表情和注视方向）是否由解剖学和功能分离的神经结构联合或独立处理。醒着的猕猴会看到一组猴脸，表现出攻击性、中性和安抚的表情，头和眼睛要么避开，要么转向。与傅里叶相位扰乱图像相比，对这些面孔的大胆反应揭示了颞上沟和颞下皮层的广泛激活，包括杏仁核的活动。面部刺激的不同维度引起了杏仁核之间不同的激活模式。基底外侧杏仁核，包括外侧基底核、基底核和附属基底核，对威胁性表情产生比安抚性表情更强的反应。终纹的中央核和床核对避开的面孔的反应比对直视面孔的反应更大。独立的行为测量证实，目光转移的面孔更能唤起性欲，这表明中央核的活动可能与注意力和唤起性有关。
The social behavior of both human and nonhuman primates relies on specializations for the recognition of individuals, their facial expressions, and their direction of gaze [1-5]. A broad network of cortical and subcortical structures has been implicated in face processing, yet it is unclear whether co-occurring dimensions of face stimuli, such as expression and direction of gaze, are processed jointly or independently by anatomically and functionally segregated neural structures. Awake macaques were presented with a set of monkey faces displaying aggressive, neutral, and appeasing expressions with head and eyes either averted or directed. BOLD responses to these faces as compared to Fourier-phase-scram bled images revealed widespread activation of the superior temporal sulcus and inferotemporal cortex and included activity in the amygdala. The different dimensions of the face stimuli elicited distinct activation patterns among the amygdaloid nuclei. The basolateral amygdala, including the lateral, basal, and accessory basal nuclei, produced a stronger response for threatening than appeasing expressions. The central nucleus and bed nucleus of the stria terminalis responded more to averted than directed-gaze faces. Independent behavioral measures confirmed that faces with averted gaze were more arousing, suggesting the activity in the central nucleus may be related to attention and arousal.