A microstructurally informed model for the mechanical response of three-dimensional actin networks.
A microstructurally informed model for the mechanical response of three-dimensional actin networks.
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DOI：
10.1080/10255840801888686
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发表时间：
2008-08
影响因子：
1.6
通讯作者：
Jacobs CR
中科院分区：
文献类型：
--
作者：
Kwon RY;Lew AJ;Jacobs CR
我们提出了一类微观结构知情的交联聚合物网络，如肌动蛋白细胞骨架的线性弹性力学行为的模型。该模型的显着特点包括代表各向异性长丝分布产生的各向异性力学行为的可能性，和幂律缩放的机械性能与长丝密度。类中的机械模型由七个不同的常数参数化。我们展示了一个程序，用于确定这些常数使用三维肌动蛋白网络的有限元模型。肌动蛋白丝和交联被建模为弹性杆，并在生理体积分数和图像体素的规模构建网络。我们展示了该模型的性能，在估计的力学行为的网络在很宽的范围内的细丝密度和程度的各向异性。
We propose a class of microstructurally informed models for the linear elastic mechanical behavior of cross-linked polymer networks such as the actin cytoskeleton. Salient features of the models include the possibility to represent anisotropic mechanical behavior resulting from anisotropic filament distributions, and a power-law scaling of the mechanical properties with the filament density. Mechanical models within the class are parameterized by seven different constants. We demonstrate a procedure for determining these constants using finite element models of three-dimensional actin networks. Actin filaments and cross-links were modeled as elastic rods, and the networks were constructed at physiological volume fractions and at the scale of an image voxel. We show the performance of the model in estimating the mechanical behavior of the networks over a wide range of filament densities and degrees of anisotropy.
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影响因子：
3.2
作者：
Chatterjee, Avik P.
通讯作者：
Chatterjee, Avik P.
影响因子：
1.6
作者：
Dodson, CTJ;Sampson, WW
通讯作者：
Sampson, WW
影响因子：
44.1
作者：
GOUDSMIT, S
通讯作者：
GOUDSMIT, S
影响因子：
3.7
作者：
Foygel, M;Morris, RD;Sobolev, VL
通讯作者：
Sobolev, VL
影响因子：
7.8
作者：
HARTWIG, JH;SHEVLIN, P
通讯作者：
SHEVLIN, P