Clinical and Ophthalmic Factors Associated With the Severity of Sickle Cell Retinopathy
Clinical and Ophthalmic Factors Associated With the Severity of Sickle Cell Retinopathy
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DOI：
10.1016/j.ajo.2018.09.025
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发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Scott, Adrienne W.
中科院分区：
文献类型：
--
作者：
Duan, Xiangyun J.;Lanzkron, Sophie;Scott, Adrienne W.
目的：确定镰状细胞视网膜病变（SCR）的严重程度与镰状细胞病（SCD）相关的其他临床、实验室或治疗因素之间的关联。
设计：回顾性队列研究。
方法：我们在我们的镰状细胞病专科诊所和视网膜诊所就诊的296名患者中研究了与SCR严重程度相关的临床、实验室和人口统计学关联。使用多变量多项逻辑回归来估计每个临床变量与SCR严重程度之间的关联。
结果：多变量分析显示，在镰状细胞贫血（SCA）基因型患者中，年龄较大（95%置信区间[CI]，1.04 - 1.15；P
（最后一个单词“P”后面似乎内容不完整，如果还有遗漏信息，请补充完整后再次提问。）
PURPOSE: To identify associations between severity of sickle cell retinopathy (SCR) and other clinical, laboratory, or treatment factors relevant to sickle cell disease (SCD).DESIGN: Retrospective cohort study.METHODS: We investigated clinical, laboratory, and demographic associations with the severity of SCR in 296 patients seen at both our SCD specialty clinic and our retina clinic. Multivariate multinomial logistic regression was used to estimate the association between each clinical variable and severity of SCR.RESULTS: Multivariate analysis showed that in patients with sickle cell anemia (SCA) genotypes, older age (95% confidence interval [CI], 1.04-1.15; P