Reconstruction of the Ascending Reticular Activating System with Diffusion Tensor Tractography in Patients with a Disorder of Consciousness after Traumatic Brain Injury.
Reconstruction of the Ascending Reticular Activating System with Diffusion Tensor Tractography in Patients with a Disorder of Consciousness after Traumatic Brain Injury.
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DOI：
10.7759/cureus.1723
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发表时间：
2017-09-28
期刊：
影响因子：
--
通讯作者：
Cifuentes-Lobelo HA
中科院分区：
文献类型：
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作者：
Ordóñez-Rubiano EG;Johnson J;Enciso-Olivera CO;Marín-Muñoz JH;Cortes-Lozano W;Baquero-Herrera PE;Ordóñez-Mora EG;Cifuentes-Lobelo HA
这项工作描述了三名创伤性脑损伤后意识改变的患者通过弥散张量纤维束成像重建网状上行激活系统 (ARAS)。 对三名严重创伤性脑损伤后意识受损的患者进行了弥散张量纤维束成像。使用1.5T扫描仪获取张量序列；获得了轴向张量。进行后处理，并记录平均分数各向异性 (FA) 值。 FA 图用于手动追踪以下感兴趣区域 (ROI)：腹内侧中脑、前丘脑和下丘脑。病例 1 表现为右侧背侧和腹侧被盖束破坏以及右侧中前脑束的破坏，病例 2 表现为右侧背侧被盖束的破坏，病例 3 表现为双侧腹侧和背侧被盖束的破坏以及右侧中前脑束的破坏。描述了三名创伤性脑损伤后意识障碍（DOC）患者的网状上行激活系统受影响的纤维，以及弥漫性轴突损伤的网状上行激活系统的 FA 值异常。
This work describes the reconstruction of the ascending reticular activating system (ARAS) with diffusion tensor tractography in three patients with altered consciousness after traumatic brain injury. A diffusion tensor tractography was performed in three patients with impaired consciousness after a severe traumatic brain injury. A 1.5 T scanner was used to obtain the tensor sequences; axial tensors were acquired. Post-processing was performed, and the mean fractional anisotropy (FA) values were recorded. The FA maps were used to do a manual tracing of the following regions of interest (ROIs): the ventromedial midbrain, the anterior thalamus, and the hypothalamus. Case 1 presented destruction of the right dorsal and ventral tegmental tracts as well as destruction of the right middle forebrain bundle, case 2 had destruction of the right dorsal tegmental tract, and case 3 had destruction of the bilateral ventral and dorsal tegmental tracts, as well as destruction of the right middle forebrain bundle. The affected fibers of the ascending reticular activating system with diffuse axonal injury and the FA values abnormalities in the ascending reticular activating system in three patients with a disorder of consciousness (DOC) after traumatic brain injury are described.