Seroprevalence of antibodies to HTLV‐I In patients with chronic neurological disorders other than tropical spastic paraparesis
Seroprevalence of antibodies to HTLV‐I In patients with chronic neurological disorders other than tropical spastic paraparesis
复制标题
热带痉挛性截瘫以外的慢性神经系统疾病患者中 HTLV-I 抗体的血清阳性率
作者：
C. Mora;R. Garruto;P. Brown;D. Guiroy;O. Morgan;P. Rodgers;M. Ceroni;R. Yanagihara;L. Goldfarb;C. Gibbs;D. Gajdusek
人类嗜T淋巴细胞病毒I型（HTLV-I）是成人T细胞白血病/淋巴瘤的病原体，也似乎是热带痉挛性下肢轻瘫的原因，这是一种在世界多个不同地区报告的慢性脊髓病。研究了除热带痉挛性轻瘫以外的慢性神经退行性疾病患者和一些肌肉炎症性疾病患者中HTLV‐I抗体的患病率。在82名患有肌萎缩侧索硬化症和帕金森综合征-痴呆的关岛患者、164名关岛正常对照、10名来自巴布亚新几内亚东部高地的库鲁病患者、4名来自西伯利亚东部Iakut地区的Viliuisk脑脊髓炎患者、45名患有多发性硬化症的意大利患者、56例多发性肌炎患者（49例来自美国，7例来自牙买加）。通过酶联免疫吸附试验、蛋白质免疫印迹和明胶颗粒凝集技术测定，在关岛的1例肌萎缩侧索硬化症患者和1例对照受试者、1例美国患者和所有7例牙买加多发性肌炎患者中发现了HTLV-I感染的血清学证据。除了牙买加多发性肌炎患者组的高血清阳性率外，我们的数据表明HTLV-I在所检查的神经系统疾病谱中不太可能是致病因子。7例牙买加多发性肌炎患者的血清学阳性需要进一步研究。
Human T‐lymphotropic virus type I (HTLV‐I), the etiological agent of adult T‐cell leukemia/lymphoma, also appears to be the cause of tropical spastic paraparesis, a chronic myelopathy reported in several different regions of the world. The prevalence of antibodies to HTLV‐I in patients with chronic neurodegenerative disorders other than tropical spastic paraparesis and in patients with some muscle inflammatory disorders has been investigated. IgG antibodies to HTLV‐I were measured in the sera and/or cerebrospinal fluid from 82 Guamanian patients with amyotrophic lateral sclerosis and parkinsonism‐dementia, 164 Guamanian normal controls, 10 patients with kuru from the Eastern High‐lands of Papua New Guinea, 4 patients with Viliuisk encephalomyelitis from the Iakut region of eastern Siberia, 45 Italian patients with multiple sclerosis, and 56 patients with polymyositis (49 from the United States and 7 from Jamaica). As determined by enzyme‐linked immunosorbent assay, Western immunoblot, and gelatin particle agglutination techniques, serological evidence of HTLV‐I infection was found in 1 patients with amyotrophic lateral sclerosis and 1 control subject from Guam, and in 1 patient from the United States and all 7 Jamaican patients with polymyositis. Except for the high seropositivity rate among the group of Jamaican patients with polymyositis, our data indicate that HTLV‐I is an unlikely causative agent in the spectrum of the neurological diseases examined. The seropositivity of the 7 Jamaican patients with polymyositis requires further study.