Hookworm vaccines
Hookworm vaccines
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DOI：
10.1086/524070
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发表时间：
2008-01-15
影响因子：
11.8
通讯作者：
Hotez, Peter J.
中科院分区：
文献类型：
--
作者：
Diemert, David J.;Bethony, Jeffrey M.;Hotez, Peter J.
由土壤传播线虫、美洲钩虫和十二指肠钩虫引起的钩虫感染是世界范围内最常见的寄生虫感染之一。虽然它不是造成大量死亡的直接原因，但它以慢性贫血和蛋白质营养不良的形式导致了严重的发病率。目前基于周期性大规模驱虫剂管理的全球控制努力是不可持续的，必须制定新的控制战略。本文综述了钩虫疫苗的研究进展，包括美洲钩虫分泌蛋白2钩虫疫苗的临床前和初步临床试验。计划要求最终开发一种结合至少两种钩虫抗原的疫苗--一种针对生命周期的幼虫阶段，另一种针对生活在胃肠道的成虫。
Hookworm infection caused by the soil-transmitted nematodes Necator americanus and Ancylostoma duodenale is one of the most common parasitic infections worldwide. Although not directly responsible for substantial mortality, it causes significant morbidity in the form of chronic anemia and protein malnutrition. Current global control efforts based on periodic mass anthelmintic administration are unsustainable, and new control strategies must be developed. This review describes progress in the development of vaccines against hookworm infection, including the preclinical and initial clinical testing of the N. americanus Ancylostoma Secreted Protein-2 Hookworm Vaccine. Plans call for eventual development of a vaccine that will combine at least 2 hookworm antigens-one targeting the larval stage of the life cycle and another targeting the adult worm living in the gastrointestinal tract.