The cytoarchitecture of sulcal folding in Heschl's sulcus and the temporal cortex in the normal brain and schizophrenia: lamina thickness and cell density
The cytoarchitecture of sulcal folding in Heschl's sulcus and the temporal cortex in the normal brain and schizophrenia: lamina thickness and cell density
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DOI：
10.1016/j.neulet.2004.06.041
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发表时间：
2004-09-09
影响因子：
2.5
通讯作者：
Crow, TJ
中科院分区：
文献类型：
--
作者：
Chance, SA;Tzotzoli, PM;Crow, TJ
发育和精神疾病，包括精神分裂症，可能与皮质厚度和折叠改变有关。进行了两项研究：（1）评估脑沟周围的皮质分层;在10名对照组和10名精神分裂症患者的组织中，在Heschl沟周围解剖学定义的点处评估皮质厚度、颗粒上（I-III）：颗粒下（IV-VI）层的相对厚度和细胞密度。(2)从6名对照组和10名精神分裂症患者的颞叶内的各个沟中采集对比突出的沟的深度、宽度、板层厚度和板层II-VI的细胞密度。独立于诊断;颞叶皮层中沟突的增加伴随着板层厚度的减少（特别是第V层和第VI层），深层显示细胞密度和层厚度之间的负相关，并且与顶部相比，Heschl沟中的总皮层宽度在底部减少一半。此外，相比于颗粒上层，颗粒下分裂是相对较厚的顶部的回，平等的沟壁和相对较薄的底部。许多影响沟折叠层的比例在控制中是类似的精神分裂症。然而，在精神分裂症患者的颞叶某些脑沟底部，细胞密度较低。采样方法应考虑皮质折叠影响细胞和薄层分布在采样区域中的高度本地化的方式。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
Developmental and psychiatric disorders, including schizophrenia, may be associated with altered cortical thickness and folding. Two studies were performed: (1) to assess cortical layering around a sulcus; cortical thickness, relative thickness of the supragranular (I-III):infragranular (IV-VI) layers, and cell density were assessed at anatomically defined points around Heschl's sulcus in tissue from 10 controls and 10 schizophrenia patients. (2) To sample sulci of contrasting prominence; sulcal depth, width, lamina thickness, and cell density from laminae II-VI were taken from various sulci within the temporal lobes from another group of 6 controls and 10 patients.Reduced cell density was found in the fundi of sulci in schizophrenia. Independent of diagnosis; increased sulcal prominence in temporal cortex accompanies reduced lamina thickness (particularly layers V and VI), deep layers show negative relationships between cell density and layer thickness, and total cortex width in Heschl's sulcus reduces by half at the bottom compared to the top. Furthermore, compared to the supragranular layers, the infragranular division is relatively thicker at the top of a gyrus, equal in the wall of the sulcus and relatively thinner at the bottom.Many effects of sulcal folding on laminar proportions in controls are similar in schizophrenia. However, cell density is less at the bottom of some sulci in the temporal lobe in schizophrenia. Sampling methods should consider that cortical folding affects cell and lamina distribution in the sampled region in a highly localised manner. (C) 2004 Elsevier Ireland Ltd. All rights reserved.