Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors
Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors
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DOI：
10.1038/386239a0
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发表时间：
1997-03-20
期刊：
影响因子：
64.8
通讯作者：
Bettler, B
中科院分区：
文献类型：
--
作者：
Kaupmann, K;Huggel, K;Bettler, B
GABA（γ -氨基丁酸）是大脑中主要的抑制性神经递质，通过嗜离子性(GABA（A)/ GABA(C)）和代谢性（GABA(B)）受体系统发出信号。本文报道了GABA(B)受体的克隆。光亲和标记实验表明，克隆的受体对应于脊椎动物神经系统中存在的两种高度保守的GABA(B)受体形式。克隆的受体与腺苷酸环化酶负偶联，序列与兴奋性神经递质l -谷氨酸的代谢受体相似。
GABA (gamma-amino-butyric acid), the principal inhibitory neurotransmitter in the brain, signals through ionotropic (GABA(A)/ GABA(C)) and metabotropic (GABA(B)) receptor systems. Here we report the cloning of GABA(B) receptors. Photoaffinity labelling experiments suggest that the cloned receptors correspond to two highly conserved GABA(B) receptor forms present in the vertebrate nervous system. The cloned receptors negatively couple to adenylyl cyclase and show sequence similarity to the metabotropic receptors for the excitatory neurotransmitter L-glutamate.