Vascular Endothelial Growth Factor +936C/T and +405G/C Polymorphisms and Cancer Risk: a Meta-analysis
Vascular Endothelial Growth Factor +936C/T and +405G/C Polymorphisms and Cancer Risk: a Meta-analysis
复制标题
DOI：
10.1016/j.arcmed.2010.09.006
复制
发表时间：
2010-10-01
影响因子：
7.7
通讯作者：
Deng, Zai-Chun
中科院分区：
文献类型：
--
作者：
Cao, Ch'ao;Fang, Jing-Jing;Deng, Zai-Chun
背景和目标。许多研究人员研究了血管内皮生长因子 (VEGF) 多态性与癌症风险之间可能存在的关联，但结果相互矛盾。为了检查与 VEGF +936C/T 和 +405G/C 多态性相关的癌症风险，本荟萃分析考虑了所有可用的研究。方法。我们对 PubMed 和 Embase 数据库进行了计算机检索以获取相关研究。对符合纳入标准的文章进行了系统审查，并使用荟萃分析的统计技术汇总了报告的数据。结果。总体而言，在所有受试者中，与 936T 等位基因相比，936C 等位基因对癌症风险没有显着影响（OR = 0.77，95% CI = 0.53-1.14；随机模型）。同样，与 405C 相比，405G 等位基因对癌症风险没有显着影响（OR = 1.08，95% CI = 0.94-1.24；随机模型）。表明VEGF+936C/T和+405G/C多态性可能不是癌症危险因素，但936C等位基因与口腔癌风险降低相关（OR=0.72，95%CI=0.53-0.97；固定模型）。结论。我们的荟萃分析证据支持 936C 等位基因与口腔癌风险降低之间存在关联，尽管在所有检查的患者中没有观察到 VEGF +936C/T 或 +405G/C 多态性与癌症之间存在关联的证据。需要基于更大的分层人群的进一步研究来探索 VEGF 多态性对癌症风险的作用。 (C) 2010 年IMSS。由爱思唯尔公司出版
Background and Aims. A number of investigators have studied the possible association between vascular endothelial growth factor (VEGF) polymorphisms and cancer risk, but the results have been conflicting. To examine the risk of cancer associated with the +936C/T and +405G/C polymorphisms of VEGF, all available studies were considered in the present meta-analysis.Methods. We performed a computerized search of PubMed and Embase database for relevant studies. Articles meeting the inclusion criteria were reviewed systematically, and the reported data were aggregated using the statistical techniques of meta-analysis.Results. Overall, the 936C allele showed no significant effect on cancer risk compared with the 936T allele in all subjects (OR = 0.77, 95% CI = 0.53-1.14; random model). Similarly, no significant effect of 405G allele compared with 405C on cancer risk was found (OR = 1.08, 95% CI = 0.94-1.24; random model). It indicated that the VEGF +936C/T and +405G/C polymorphisms might not be risk factors for cancer, but the 936C allele was associated with a decreased risk of oral cancer (OR = 0.72, 95% CI = 0.53-0.97; fixed model).Conclusions. The evidence from our meta-analysis supports that there was an association between 936C allele and decreased oral cancer risk, although no evidence of association between VEGF +936C/T or +405G/C polymorphism and cancer was observed in all examined patients. Further studies based on larger, stratified population are required to explore the role of VEGF polymorphisms on cancer risk. (C) 2010 IMSS. Published by Elsevier Inc.