Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development.
Long form of latent TGF-β binding protein 1 (Ltbp1L) regulates cardiac valve development.
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DOI：
10.1002/dvdy.22521
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发表时间：
2011-01
影响因子：
2.5
通讯作者：
Rifkin, Daniel B.
中科院分区：
文献类型：
--
作者：
Todorovic, Vesna;Finnegan, Erin;Freyer, Laina;Zilberberg, Lior;Ota, Mitsuhiko;Rifkin, Daniel B.
Transforming Growth Factor β (TGF-β) is crucial for valve development and homeostasis. The long form of Latent TGF-β binding protein 1 (LTBP1L) covalently binds all TGF-β isoforms and regulates their bioavailability. Ltbp1L expression analysis during valvulogenesis revealed two patterns of Ltbp1L production: an early one (E9.5–11.5) associated with endothelial to mesenchymal transformation (EMT); and a late one (E12.5-birth) contemporaneous with valve remodeling. Similarly, histological analysis of Ltbp1L−/− developing valves identified two different pathologies: generation of hypoplastic endocardial cushions in early valvulogenesis, followed by development of hyperplastic valves in late valvulogenesis. Ltbp1L promotes valve EMT, as Ltbp1L absence yields hypoplastic endocardial cushions in vivo and attenuated EMT in vitro. Ltbp1L−/− valve hyperplasia in late valvuogenesis represents a consequence of prolonged EMT. We demonstrate that Ltbp1L is a major regulator of Tgf-β activity during valvulogenesis since its absence results in a perturbed Tgf-β pathway that causes all Ltbp1L−/− valvular defects.
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影响因子：
4.6
作者：
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DOI：
10.1083/jcb.200111080
发表时间：
2002-01-21
期刊：
The Journal of cell biology
影响因子：
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作者：
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通讯作者：
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影响因子：
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