Association Between Circulating Endostatin, Hypertension Duration, and Hypertensive Target-Organ Damage
Association Between Circulating Endostatin, Hypertension Duration, and Hypertensive Target-Organ Damage
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DOI：
10.1161/hypertensionaha.113.02250
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发表时间：
2013-12-01
期刊：
影响因子：
8.3
通讯作者：
Arnlov, Johan
中科院分区：
文献类型：
--
作者：
Carlsson, Axel C.;Ruge, Toralph;Arnlov, Johan
我们的目的是研究循环内皮抑素、高血压病程和高血压靶器官损害之间的关系。长期高血压可导致心血管和肾脏重塑。循环内皮抑制素是胶原蛋白XVIII的生物活性衍生物，已被认为是各种疾病中细胞外基质转换和重塑的相关标志物。然而，内皮抑素在高血压和高血压靶器官损害中的作用尚不清楚。在2个独立的基于社区的队列中测量血清内皮抑素：乌普萨拉老年人血管系统的前瞻性研究（PIVUS;女性51%; n=812;平均年龄75岁）和乌普萨拉成年男性纵向研究（ULSAM; n=785;平均年龄77.6岁）。血压测量和抗高血压药物治疗的回顾性数据（PIVUS >5年，ULSAM >27年），以及超声心动图左心室质量、内皮功能（通过侵入性前臂模型评估的内皮依赖性血管舒张）和尿白蛋白/肌酐比值的横断面数据。在PIVUS中，有5年高血压史的参与者描绘了0.42 SD（95%置信区间，0.23-0.61; P
Our aim is to study associations between circulating endostatin, hypertension duration, and hypertensive target-organ damage. Long-term hypertension induces cardiovascular and renal remodeling. Circulating endostatin, a biologically active derivate of collagen XVIII, has been suggested to be a relevant marker for extracellular matrix turnover and remodeling in various diseases. However, the role of endostatin in hypertension and hypertensive target-organ damage is unclear. Serum endostatin was measured in 2 independent community-based cohorts: the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS; women 51%; n=812; mean age, 75 years) and the Uppsala Longitudinal Study of Adult Men (ULSAM; n=785; mean age, 77.6 years). Retrospective data on blood pressure measurements and antihypertensive medication (PIVUS >5 years, ULSAM >27 years), and cross-sectional data on echocardiographic left ventricular mass, endothelial function (endothelium-dependent vasodilation assessed by the invasive forearm model), and urinary albumin/creatinine ratio were available. In PIVUS, participants with 5 years of history of hypertension portrayed 0.42 SD (95% confidence interval, 0.23-0.61; P