Influence of gut microbiota dysbiosis on brain function: a systematic review.
Influence of gut microbiota dysbiosis on brain function: a systematic review.
复制标题
DOI：
10.1097/j.pbj.0000000000000059
复制
发表时间：
2020-03
期刊：
影响因子：
--
通讯作者：
Barata P
中科院分区：
文献类型：
--
作者：
Almeida C;Oliveira R;Soares R;Barata P
近世纪来，人们已经认识到人类拥有一个多样而密集的微生物生态系统，称为人类微生物群，但我们仍然开始了解这些微生物在人类健康和发展中发挥的许多作用。据认为，在某些情况下，如生态失调，微生物群可以引起疾病，其中中枢神经系统（CNS）具有重要的相关性，并且“肠-脑轴”将发挥主要作用。本文综述了肠道微生物群对脑功能的影响，试图证明微生态失调是否会影响CNS疾病，或者是否是疾病导致微生态失调，突出了该领域的现有文献。我们在EMBASE、PubMed和科克伦中结合术语“肠道微生物群”、“生态失调”和“中枢神经系统疾病”进行了系统性文献检索，以确定那些报告肠道微生物群生态失调和中枢神经系统疾病之间存在某种影响或关系的文献。对于本系统评价，我们仅纳入系统评价或荟萃分析。对EMBASE、PubMed和科克伦进行了系统性检索，仅考虑系统性综述或荟萃分析。本综述纳入了9项研究，包括705篇文章。这9篇系统性综述包括2篇关于自闭症谱系障碍的综述，1篇关于痴呆症的综述，1篇关于抑郁症的综述，2篇关于自身免疫性疾病的综述，1篇关于精神分裂症的综述，2篇关于某些脑功能改变的综述。表征几种神经疾病的现有数据表明生态失调与CNS疾病之间存在显著相关性，加强了肠道微生物群生态失调可能与CNS患者异常相关的证据。虽然显然需要更多的研究来更好地了解肠道微生物群在CNS疾病中的作用，但微生物群对神经系统的调节是明确的，继续成为持续研究的主题。我们需要充分了解微生物群与人类大脑相互作用的机制，以及生态失调与抑郁症、痴呆症、自闭症或精神分裂症等病理之间的联系。
For almost a century it has been recognized that human possess a varied and dens microbial ecosystem called the human microbiota, yet we are still beginning to understand many of the roles that these microorganisms play in human health and development. It is thought that under certain circumstances such as dysbiosis, the microbiota can cause diseases, where the central nervous system (CNS) has an important relevance and where the “gut-brain axis” will play a major role. This review investigated the influence of the gut microbiota on brain function, trying to demonstrate whether dysbiosis influences CNS diseases or whether it is the disease that causes dysbiosis, highlighting the existing literature within this field. We performed a systematic literature search in EMBASE, PubMed, and Cochrane combining the terms “gut microbiota,” “dysbiosis,” and “CNS diseases” to identify those whom reported some influence or relation between dysbiosis of gut microbiota and CNS diseases. For the present systematic review, we only included systematic reviews or meta-analysis. The EMBASE, PubMed, and Cochrane were systematically searched, considering only systematic reviews or meta-analysis. Nine studies comprising 705 articles were included in this review. Those 9 systematic reviews consist in 2 about autism spectrum disorder, 1 in dementia, 1 in depression, 2 in autoimmune diseases, 1 in schizophrenia, and 2 in some altered brain function. Available data characterizing several neural diseases demonstrate a significant correlation between dysbiosis and CNS diseases, strengthen the evidence that dysbiosis of gut microbiota may correlate with abnormalities in CNS patients. Although there is a clear need for more investigations to better understand the role of the gut microbiota in CNS diseases, the modulation of the nervous system by the microbiota is clear, continuing to be the subject of continuous research. We need to fully understand the mechanisms by which the microbiota interacts with the human brain, and therefore what's the connection between dysbiosis and pathologies such depression, dementia, autism, or schizophrenia.