Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness
Bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness
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DOI：
10.1016/j.ijpsycho.2008.08.010
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发表时间：
2009-04-01
影响因子：
3
通讯作者：
Tranel, D.
中科院分区：
文献类型：
--
作者：
Khalsa, S. S.;Rudrauf, D.;Tranel, D.
内感受被定义为对内部身体状态的感知，在经典和当代情感理论中发挥着核心作用。特别是，人们假设偏离基线身体状态是情绪和感觉体验不可或缺的一部分。因此，可靠的内感受测量对于情感理论的测试至关重要。心跳感知任务被认为是评估内感受意识的标准方法，主要是由于其非侵入性和技术可行性。然而，这些任务受到以下事实的限制：心跳检测的上述机会组表现率（或“良好检测器”的频率）很少高于 40%，这意味着此类任务（因为它们通常被使用）无法在大多数人中获得内感受意识的测量。在这里，我们描述了一种新的方案，通过推注异丙肾上腺素（一种非选择性β肾上腺素能激动剂）来诱导和评估一系列身体状态偏差。使用随机、双盲和安慰剂对照的实验设计，我们发现推注异丙肾上腺素会以剂量依赖性方式引起心率快速且短暂的增加以及伴随的心跳和呼吸感觉的评级。我们的协议揭示了所有 15 名测试参与者的内感受意识的变化，从而克服了心跳检测任务的主要限制。这些发现表明，推注异丙肾上腺素提供了一种评估内感受意识的可靠方法，这为进一步研究内感受感觉在情绪体验中的作用奠定了基础。 (C) 2008 Elsevier B.V. 保留所有权利。
Interoception, defined as the perception of internal body states, plays a central role in classic and contemporary theories of emotion. In particular, deviations from baseline body states have been hypothesized to be integral to the experience of emotion and feeling. Consequently, reliable measurement of interoception is critical to the testing of emotion theories. Heartbeat perception tasks have been considered the standard method for assessing interoceptive awareness, primarily due to their non-invasive nature and technical feasibility. However, these tasks are limited by the fact that above chance group performance rates on heartbeat detection (or the frequency of 'good detectors') are rarely higher than 40%, meaning that such tasks (as they are typically utilized) do not obtain a measure of interoceptive awareness in the majority of individuals. Here we describe a novel protocol for inducing and assessing a range of deviations in body states via bolus infusions of isoproterenol, a non-selective beta adrenergic agonist. Using a randomized, double-blinded, and placebo-controlled experimental design, we found that bolus isoproterenol infusions elicited rapid and transient increases in heart rate and concomitant ratings of heartbeat and breathing sensations, in a dose-dependent manner. Our protocol revealed changes in interoceptive awareness in all 15 participants tested, thus overcoming a major limitation of heartbeat detection tasks. These findings indicate that bolus isoproterenol infusions provide a reliable method for assessing interoceptive awareness, which sets a foundation for further investigation of the role of interoceptive sensations in the experience of emotion. (C) 2008 Elsevier B.V. All rights reserved.