Relationship between Indoor Daytime Light Exposure and Circadian Phase Response under Laboratory Free-Living Conditions
Relationship between Indoor Daytime Light Exposure and Circadian Phase Response under Laboratory Free-Living Conditions
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DOI：
10.1080/09291016.2020.1782691
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发表时间：
2020-06-24
影响因子：
1.1
通讯作者：
Mishima，Kazuo
中科院分区：
文献类型：
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作者：
Yoshimura，Michitaka;Kitamura，Shingo;Mishima，Kazuo
在这项研究中，我们测量了光的物理量（辐照度）在几个波段的眼睛和手腕水平8小时，在实验室条件下模拟日常生活。22名健康男性参与者（平均年龄± SD，29.95 ± 8.13岁）能够自由移动，并将眼睛水平数据与手腕处获得的辐照度数据进行比较。在考虑自然漂移的情况下，我们从光暴露前后DLMO的差异估计了昼夜节律相移。此外，我们还研究了活动和体位对光照的影响，并验证了光照对昼夜相位反应的影响。我们发现在所有三个RGB波段中，与手腕水平相比，眼睛水平的平均辐照度较低。在眼睛水平处测量的蓝光辐照度与昼夜节律相移显著相关，这可能是因为眼睛水平处的辐照度比手腕处的测量更准确地反映了其对生物钟的影响。因此，在眼睛水平的波长光谱的定量测量是必要的，以评估环境光对人体生物钟的影响。
In this study, we measured the physical quantity of light (irradiance) in several wavelength bands at eye and wrist level for 8 h under laboratory conditions simulating daily life. Twenty-two healthy male participants (mean age ± SD, 29.95 ± 8.13 years) were able to move freely, and eye-level data were compared with irradiance data obtained at the wrist. We estimated circadian phase shift from the differences of DLMO before and after light exposure while considering natural drift. In addition, we investigated the influence of activities and body positions on light exposure and validated the effect of irradiance on circadian phase response. We found lower average irradiance at eye level compared with wrist level in all three RGB bands. The blue light irradiance measured at eye level was significantly correlated with circadian phase shift, possibly because the irradiance at eye level more accurately reflected its effect on the biological clock than did the measurement at the wrist. It follows that quantitative measurements of wavelength spectra at eye level are necessary to assess the effect of ambient light on the human biological clock.