EFFECTS OF INTERMITTENT FEEDING UPON GROWTH AND LIFE-SPAN IN RATS
EFFECTS OF INTERMITTENT FEEDING UPON GROWTH AND LIFE-SPAN IN RATS
复制标题
DOI：
10.1159/000212538
复制
发表时间：
1982-01-01
期刊：
影响因子：
3.5
通讯作者：
CIDER, NL
中科院分区：
文献类型：
--
作者：
GOODRICK, CL;INGRAM, DK;CIDER, NL
从断奶到死亡，28只雄性Wistar大鼠维持自由（AL）饮食，24只对应大鼠每隔一天（EOD）提供饮食。EOD组的平均寿命比AL组增加了83%。Gompertzian死亡率分析表明，EOD组的衰老速度减慢。虽然EOD组的体重和生长速度降低，但其生长持续时间比AL组长75%。AL组的寿命和生长速度参数之间出现显着的正相关关系，但是，EOD组的寿命和体重参数之间没有显着的关系。为了支持饮食限制通过发育迟缓影响长寿的假设，仅在AL和EOD喂养动物的组间比较中获得了证据。
From weaning to death, 28 male Wistar rats were maintained on an ad lib (AL) diet, and 24 counterparts were provided the diet every-other-day (EOD). The mean life span of the EOD group represented an 83% increase over that of the AL group. A Gompertzian analysis of mortality rates suggested that the rate of aging was retarded in the EOD group. While body weight and growth rate were reduced in the EOD group, their growth duration was 75% longer compared to the AL group. Significant positive relationships emerged between life span and growth rate parameters in the AL group; however, no significant relationships were found between life span and body weight parameters in the EOD group. In support of the hypothesis that dietary restriction effects prolongevity through retarded development, evidence was produced only in the between-group comparisons of AL- and EOD-fed animals.