The β‐adrenoceptor of pig coronary arteries: determination of β1 and β2 subtypes by radioligand binding
The β‐adrenoceptor of pig coronary arteries: determination of β1 and β2 subtypes by radioligand binding
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猪冠状动脉的β-肾上腺素受体：通过放射性配体结合测定β1和β2亚型
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
J. Velly
中科院分区：
文献类型：
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作者：
J. Schwartz;J. Velly
用新配体125碘氰基吲哚酚（ICYP）研究了猪冠状动脉1 β-肾上腺素受体的结合情况。2倍他洛尔（一种选择性β1受体拮抗剂）、锌特罗（一种选择性β2受体激动剂）和ICI 118551（一种选择性β2受体阻断剂）对ICYP结合的抑制导致非线性Scatchard图，表明猪冠状动脉中存在两种β肾上腺素受体亚型。[3]对数据的计算机分析得出β1：β2-肾上腺素受体的比例约为65：35。
1 β‐Adrenoceptors of pig coronary arteries were investigated by the use of a new ligand, 125iodocyanopindolol (ICYP) in binding studies. 2 Inhibition of ICYP binding by betaxolol (a selective β1‐antagonist), zinterol (a selective β2‐agonist) and ICI 118551 (a selective β2‐blocking drug) resulted in non‐linear Scatchard plots, suggesting that both β‐adrenoceptor subtypes are present in pig coronary arteries. 3 Computer analysis of the data gave a β1:β2‐adrenoceptor ratio of approximately 65:35.