Inhibition of Myocardial Ischemia/Reperfusion Injury by Exosomes Secreted from Mesenchymal Stem Cells.
Inhibition of Myocardial Ischemia/Reperfusion Injury by Exosomes Secreted from Mesenchymal Stem Cells.
复制标题
间充质干细胞分泌的外泌体抑制心肌缺血/再灌注损伤
DOI：
10.1155/2016/4328362
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发表时间：
2016
影响因子：
4.3
通讯作者：
Chen S
中科院分区：
文献类型：
--
作者：
Zhang H;Xiang M;Meng D;Sun N;Chen S
间充质干细胞分泌的外泌体在再生医学中显示出巨大的治疗潜力。在本研究中，我们根据 2000 年 1 月至 2015 年 9 月期间发表并在 PUBMED 和 Web of Science 数据库中索引的报告进行了荟萃分析，以评估使用外泌体治疗缺血/再灌注损伤的临床有效性。根据以下参数评估外泌体对心脏功能的影响：危险面积占左心室的百分比、梗塞面积占危险面积的百分比、梗塞面积占左心室的百分比、左心室射血分数、左心室缩短分数、舒张末期容积和收缩末期容积。我们的分析表明，目前可用的证据证实了间充质干细胞分泌的外泌体在改善心脏功能方面的治疗潜力。然而，需要进一步的机制研究、治疗安全性和临床试验来优化和验证这种缺血/再灌注损伤后心脏再生方法。
Exosomes secreted by mesenchymal stem cells have shown great therapeutic potential in regenerative medicine. In this study, we performed meta-analysis to assess the clinical effectiveness of using exosomes in ischemia/reperfusion injury based on the reports published between January 2000 and September 2015 and indexed in the PUBMED and Web of Science databases. The effect of exosomes on heart function was evaluated according to the following parameters: the area at risk as a percentage of the left ventricle, infarct size as a percentage of the area at risk, infarct size as a percentage of the left ventricle, left ventricular ejection fraction, left ventricular fraction shortening, end-diastolic volume, and end-systolic volume. Our analysis indicated that the currently available evidence confirmed the therapeutic potential of mesenchymal stem cell-secreted exosomes in the improvement of heart function. However, further mechanistic studies, therapeutic safety, and clinical trials are required for optimization and validation of this approach to cardiac regeneration after ischemia/reperfusion injury.