Anomalies in uncinate fasciculus development and social defects in preschoolers with autism spectrum disorder
Anomalies in uncinate fasciculus development and social defects in preschoolers with autism spectrum disorder
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患有自闭症谱系障碍的学龄前儿童钩束发育异常和社交缺陷
DOI：
10.1186/s12888-019-2391-1
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发表时间：
2019-12-16
期刊：
影响因子：
4.4
通讯作者：
Ke, Xiaoyan
中科院分区：
文献类型：
--
作者：
Li, Yun;Zhou, Zhengbing;Ke, Xiaoyan
背景：自闭症谱系障碍（ASD）患者存在社会交往缺陷和情绪调节困难。这些社会情感缺陷的神经基础尚不清楚，但一个潜在的候选人是钩束（UF）发育不良，一个白色物质束被认为是参与社会情感处理。然而，发展轨迹的UF在幼儿与社会交往的缺陷还没有被检查。本研究旨在描述UF的发育生长轨迹以及UF发育与ASD社交缺陷之间的关系。方法：通过基于扩散张量成像（DTI）的纤维束成像测量37名ASD儿童和27名匹配的2-3岁儿童的UF特征值基线（时间1）和2年随访（时间2）时发育迟缓（DD）的受试者。UF的增长率进行了比较组之间和协会与社会缺陷分数根据孤独症诊断访谈修订（ADI-R）分析Pearson的correlations.Results：在时间1，轴向扩散率（AD）的左UF是显着大于ASD组比DD组。在时间2，ASD组的左UF各向异性分数（FA）显著高于DD组，径向扩散率（RD）显著低于DD组。在这2年的时间间隔内，ASD儿童的UF增长速度比DD快。ADI-R社会赤字措施的上升和右UF RD和左UF平均扩散率（MD）之间存在显着的负相关性。结论：ASD的幼儿表现出UF过度生长在2年的发展期间，2和3和4-5岁，这白色物质异常与社会赤字的进展直接相关。
Background: Individuals with autism spectrum disorder (ASD) have social interaction deficits and difficulties in emotional regulation. The neural substrates for these socio-affective deficits are not yet clear, but one potential candidate is maldevelopment of the uncinate fasciculus (UF), a white matter tract thought to be involved in socio-affective processing. However, the developmental trajectory of the UF in young children with social interaction deficits has not been examined. The present study was designed to describe the developmental growth trajectory of the UF and the relationships between UF development and social deficits in ASD.Methods: Eigenvalues of the UF were measured by diffusion tensor imaging (DTI)-based tractography in 37 children with ASD and 27 matched 2-3-year-old subjects with developmental delay (DD) at baseline (time 1) and at 2-year follow-up (time 2). Growth rates of the UF were compared between groups and associations with social deficit scores according to the Autism Diagnostic Interview-Revised (ADI-R) analyzed by Pearson's correlations.Results: At time 1, axial diffusivity (AD) of the left UF was significantly larger in the ASD group than the DD group. At time 2, left UF fractional anisotropy (FA) was significantly higher and radial diffusivity (RD) significantly lower in the ASD group than the DD group. The rate of UF growth during this 2-year interval was faster in children with ASD than DD. Significant negative correlations were found between the rise in ADI-R social deficit measures and both right UF RD and left UF mean diffusivity (MD).Conclusions: Young children with ASD demonstrate UF overgrowth during the 2-year development period between 2 and 3 and 4-5 years of age, and this white matter abnormality is directly associated with the progression of social deficits.