Efficient associative memory storage in cortical circuits of inhibitory and excitatory neurons
Efficient associative memory storage in cortical circuits of inhibitory and excitatory neurons
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DOI：
10.1073/pnas.1211467109
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发表时间：
2012-12-18
影响因子：
11.1
通讯作者：
Stepanyants, Armen
中科院分区：
文献类型：
--
作者：
Chapeton, Julio;Fares, Tarec;Stepanyants, Armen
突触连通性的许多特征在皮层系统中普遍存在。皮层网络由兴奋性神经元和突触主导，连接稀疏，并以刻板分布的连接权发挥作用。我们表明，突触连接的这些基本结构和功能特征很容易产生于有效的联想记忆存储的要求。我们的理论有两个基本的预测。首先，我们预测，尽管有大量的神经元类别，但如果突触前细胞是抑制性的，那么潜在连接细胞之间的功能连接必须以50%的概率实现。其次，我们建立了连接概率与连接权重变异系数之间的唯一关系。这些预测与74个已发表的实验数据集一致，这些实验报告了不同皮层系统的突触后电位振幅的连接概率和分布。更重要的是，我们的理论解释了这些实验中得到的分布的形状。
Many features of synaptic connectivity are ubiquitous among cortical systems. Cortical networks are dominated by excitatory neurons and synapses, are sparsely connected, and function with stereotypically distributed connection weights. We show that these basic structural and functional features of synaptic connectivity arise readily from the requirement of efficient associative memory storage. Our theory makes two fundamental predictions. First, we predict that, despite a large number of neuron classes, functional connections between potentially connected cells must be realized with 50% probability if the presynaptic cell is inhibitory. Second, we establish a unique relation between probability of connection and coefficient of variation in connection weights. These predictions are consistent with a dataset of 74 published experiments reporting connection probabilities and distributions of postsynaptic potential amplitudes in various cortical systems. What is more, our theory explains the shapes of the distributions obtained in these experiments.