Antimicrobial peptide sensing and detoxification modules: unravelling the regulatory circuitry of Staphylococcus aureus
Antimicrobial peptide sensing and detoxification modules: unravelling the regulatory circuitry of Staphylococcus aureus
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DOI：
10.1111/j.1365-2958.2011.07747.x
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发表时间：
2011-08-01
影响因子：
3.6
通讯作者：
Mascher, Thorsten
中科院分区：
文献类型：
--
作者：
Gebhard, Susanne;Mascher, Thorsten
对厚壁菌门细菌对抗菌肽的耐药机制的研究揭示了独特的耐药模块，该模块由一种不寻常类型的 ATP 结合盒 (ABC) 转运蛋白与两部分调节系统配对组成。在这些系统中，ABC 转运蛋白不仅参与肽的解毒，还参与肽的检测和基因表达的调节。 Hiron 等人的手稿。 (2011) 本期发表的文章描述了金黄色葡萄球菌三个旁系同源模块之间的调节回路和分工的有趣复杂性，为这些独特系统的未来研究提供了重要的机制见解和新视角。
Investigations into the resistance mechanisms of Firmicutes bacteria against antimicrobial peptides have revealed unique resistance modules comprised of an unusual type of ATP-binding cassette (ABC) transporter, paired with a two-component regulatory system. In these systems, the ABC-transporter is not only involved in detoxification of the peptides, but also in their detection and resulting regulation of gene expression. The manuscript by Hiron et al. (2011) published in this issue describes an intriguing complexity of regulatory circuits and division of labour between the three paralogous modules in Staphylococcus aureus, providing important mechanistic insights and new perspectives for future investigations of these unique systems.