Presence of plaque neovascularization on optical frequency domain imaging predicts progression of carotid artery stenosis.
Presence of plaque neovascularization on optical frequency domain imaging predicts progression of carotid artery stenosis.
复制标题
光频域成像上斑块新生血管的存在可预测颈动脉狭窄的进展。
DOI：
10.1016/j.wneu.2019.02.249
复制
发表时间：
2019
影响因子：
2
通讯作者：
Ando Y.
中科院分区：
文献类型：
--
作者：
Miura M;Yoshimura S;Yamada K;Kanamaru T;Matsumoto K;Shindo S;Uchida K;Shirakawa M;Kawasaki M;Ando Y.
背景与目的新生血管（NV）被认为是易损斑块的重要特征之一。本研究的目的是评估NV的存在，检测使用光频域成像（OFDI），缺血性事件和颈动脉stenosis.Materials and MethodsCarotid artery plaques的进展之间的关联进行了评估，使用OFDI系统血管成形术前。NV定义为在至少3个连续图像上识别出无信号的管腔结构。比较有症状和无症状斑块以及进展性和非进展性斑块之间的NV总数。颈动脉斑块被诊断为“进行性”时，收缩期峰值流速增加之间的串行颈动脉多普勒scannes.ResultsA共36例（17症状，16进步）。有吸烟习惯的颈动脉斑块进展患者的比例显著高于颈动脉斑块非进展患者（P= 0.003）。34例（94%）患者检出NV，且有进展性颈动脉斑块的患者NV总数显著高于无进展性颈动脉斑块的患者（10.2 ± 4.8 vs.3.7 ± 2.8;P< 0.0001）。NV的数量与缺血性事件之间无相关性（症状性6.0 ± 5.1 vs.无症状性7.1 ± 5.0;P= 0.47）。在多变量logistic回归分析中，NV的数量是进行性颈动脉斑块的独立预测因子（比值比1.64每增加1 [95%置信区间1.19-2.64];P= 0.0005）。使用对外直接投资评估NV可能有助于预测进行性颈动脉斑块。
Background and PurposeNeovascularization (NV) is regarded to be one of the important features of vulnerable plaque. The purpose of this study was to evaluate associations between the presence of NV, detected using optical frequency domain imaging (OFDI), and ischemic events and the progress of carotid artery stenosis.Materials and MethodsCarotid artery plaques were evaluated using an OFDI system before angioplasty. NV was defined as no-signal tubuloluminal structures recognized on at least 3 consecutive images. The total number of NVs was compared between symptomatic and asymptomatic plaques and between progressive and nonprogressive plaques. Carotid plaque was diagnosed as “progressive” when peak systolic velocity increased between serial carotid duplex scans.ResultsA total of 36 patients (17 symptomatic, 16 progressive) were included. The percentage of patients with smoking habits was significantly higher with progressive carotid plaque than with nonprogressive carotid plaque (P= 0.003). NV was detected in 34 patients (94%), and the total number of NVs was significantly higher with progressive carotid plaque (10.2 ± 4.8 vs. 3.7 ± 2.8;P< 0.0001). There was no relationship between the number of NVs and ischemic events (symptomatic 6.0 ± 5.1 vs. asymptomatic 7.1 ± 5.0;P= 0.47). In multivariate logistic regression analysis, the number of NVs was an independent predictor of progressive carotid plaque (odds ratio 1.64 per 1 increase [95% confidence interval 1.19–2.64];P= 0.0005).ConclusionsNV was more frequently observed in progressive carotid plaques. Evaluation of NV using OFDI may be useful in predicting progressive carotid plaques.