Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases
Measurement reproducibility of perfusion fraction and pseudodiffusion coefficient derived by intravoxel incoherent motion diffusion-weighted MR imaging in normal liver and metastases
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DOI：
10.1007/s00330-012-2604-1
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发表时间：
2013-02-01
影响因子：
5.9
通讯作者：
Orton, M. R.
中科院分区：
文献类型：
--
作者：
Andreou, A.;Koh, D. M.;Orton, M. R.
确定灌注分数f、假扩散系数D（*）和扩散系数D在结直肠癌肝转移灶和正常肝脏中的测量再现性。对14例已知结直肠肝转移的患者进行两次呼吸触发超声平面DW-MRI检查，每隔1小时检查8个b值（0 ~ 900 s/mm(2)）。在每个患者的目标转移和正常肝脏周围绘制感兴趣的区域，通过最小二乘数据拟合得出ADC（所有b值），ADC（高）（b值a分/千yen100 s/mm(2)）和体内非相干运动（IVIM）参数f， D（*）和D。中位ADC、ADC（high）、f、D（*）和D值的短期测量再现性采用Bland-Altman分析。与肝实质（- 6%至+ 8%）相比，ADC、ADC（高）和D的测量再现性在结直肠肝转移中最差（- 21%至+ 25%）。转移灶的灌注敏感参数f（- 75%至+ 241%）和D(*)（- 89%至+ 2120 %）的测量重现性较差，肝脏的f（- 24%至+ 25%）和D*（- 31%至+ 59%）的测量重现性较差。从广泛使用的最小二乘IVIM拟合得出的f和D（*）估计值显示测量再现性差。应努力提高灌注敏感IVIM参数测量的可重复性。定量扩散加权MRI参数越来越多地用于临床管理决策。然而，灌注敏感的体内非相干运动（IVIM）参数显示出较差的测量再现性。肝转移灶中IVIM参数的测量再现性较正常肝差。应努力提高IVIM参数的测量再现性。
To determine the measurement reproducibility of perfusion fraction f, pseudodiffusion coefficient D (*) and diffusion coefficient D in colorectal liver metastases and normal liver.Fourteen patients with known colorectal liver metastases were examined twice using respiratory-triggered echo-planar DW-MRI with eight b values (0 to 900 s/mm(2)) 1 h apart. Regions of interests were drawn around target metastasis and normal liver in each patient to derive ADC (all b values), ADC(high) (b values a parts per thousand yen100 s/mm(2)) and intravoxel incoherent motion (IVIM) parameters f, D (*) and D by least squares data fitting. Short-term measurement reproducibility of median ADC, ADC(high), f, D (*) and D values were derived from Bland-Altman analysis.The measurement reproducibility for ADC, ADC(high) and D was worst in colorectal liver metastases (-21 % to +25 %) compared with liver parenchyma (-6 % to +8 %). Poor measurement reproducibility was observed for the perfusion-sensitive parameters of f (-75 % to +241 %) and D (*) (-89 % to +2,120 %) in metastases, and to a lesser extent the f (-24 % to +25 %) and D* (-31 % to +59 %) of liver.Estimates of f and D (*) derived from the widely used least squares IVIM fitting showed poor measurement reproducibility. Efforts should be made to improve the measurement reproducibility of perfusion-sensitive IVIM parameters.aEuro cent Quantitative diffusion-weighted MRI parameters are increasingly used for clinical management decisions.aEuro cent However perfusion-sensitive intravoxel incoherent motion (IVIM) parameters showed poor measurement reproducibility.aEuro cent Measurement reproducibility of IVIM parameters was worse in metastases than normal liver.aEuro cent Efforts to improve measurement reproducibility of IVIM parameters should be explored.