Whites have a more robust hypothalamic-pituitary-adrenal axis response to a psychological stressor than blacks
Whites have a more robust hypothalamic-pituitary-adrenal axis response to a psychological stressor than blacks
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DOI：
10.1016/j.psyneuen.2007.10.014
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发表时间：
2008-02-01
影响因子：
3.7
通讯作者：
Wand, Gary S.
中科院分区：
文献类型：
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作者：
Chong, Rachel Y.;Uhart, Magdalena;Wand, Gary S.
目的：下丘脑-垂体-肾上腺（HPA）轴对应激反应的差异可能导致对多种疾病易感性的差异。我们假设，白人将不同于黑人的HPA轴反应的心理stressor.Design：健康的受试者，年龄在18-30岁，从巴尔的摩，马里兰州招募。在最初的评估中，他们完成了测量焦虑，情绪和个性的心理测试。然后，受试者参加特里尔社会压力测试（TSST），其中包括10分钟的公开演讲和心算练习。TSST前后立即测量主观焦虑。通过GEE纵向分析方法分析了种族对皮质醇、促肾上腺皮质激素（ACTH）和催乳素对TSST反应的影响。分析控制性别，基线激素水平，社会经济因素，焦虑，情绪和人格的维度。白人的相对平均皮质醇反应比黑人高36%（95% CI：10- 67%，P = 0.004）。TSST开始后25分钟，白人的平均ACTH显着高于黑人（35%，95%CI：高16-58%，P
Objective: Differences in the hypothalamic-pituitary-adrenal (HPA) axis response to stress may confer differences in susceptibility to a variety of diseases. We hypothesized that whites would differ from blacks in HPA axis response to a psychological stressor.Design: Healthy subjects aged 18-30 were recruited from Baltimore, Maryland. At initial assessment, they completed psychometric tests measuring anxiety, mood, and personality. Subjects then participated in the Trier Social Stress Test (TSST), which consisted of 10 min of public speaking and mental arithmetic exercises. Subjective anxiety was measured immediately pre- and post-TSST. Race effects on cortisol, adrenocorticotrophin (ACTH), and prolactin responses to the TSST were analyzed by GEE longitudinal analysis methods. The analysis controlled for gender, baseline hormone levels, socioeconomic factors, anxiety, mood, and dimensions of personality.Results: Ninety-eight subjects participated in the TSST. Whites had 36% greater relative mean cortisol response than blacks (95% CI: 10-67%, P = 0.004). Whites had significantly higher mean ACTH compared to blacks at 25 min after the start of the TSST (35%, 95% CI: 16-58% greater, P