Low energy helium ion texturization of titanium and relevance to biomedical applications
Low energy helium ion texturization of titanium and relevance to biomedical applications
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DOI：
10.1016/j.surfcoat.2012.03.022
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发表时间：
2012-07
影响因子：
5.4
通讯作者：
N. A. Riedel;T. Côté;Samuel L. Bechara;K. Popat;John D. Williams
中科院分区：
文献类型：
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作者：
N. A. Riedel;T. Côté;Samuel L. Bechara;K. Popat;John D. Williams
长期以来，人们一直在研究金属的氦辐照，以了解与聚变反应堆和氚储存应用相关的损害方面。这项工作探讨了使用低能量氦离子轰击作为一种方法，产生一个有益的表面纹理，以促进骨生长的骨科植入物的可能性。使用300eV的氦离子，当衬底保持在大约450°C和600°C的温度时，产生了两个独特的多孔钛表面。通过扫描电子显微镜（SEM）和扫描白色光干涉测量法对表面进行物理表征。使用未经处理的钛对照进行为期一周的hFOB 1.19细胞培养，以评价这些表面对骨科植入物的适用性。通过钙黄绿素AM活细胞染色、MTT测定和SEM评价细胞健康和活力。结果表明，氦组织化促进细胞活性，对细胞健康没有不利影响。
Helium irradiation of metals has long been studied in efforts to understand the damaging aspects associated with applications in fusion reactors and tritium storage. This work examines the possibility of using low energy helium ion bombardment as a method of producing a beneficial surface texturization to promote bone growth on orthopedic implants. Using 300eV helium ions, two unique porous titanium surfaces were created when substrates were held at temperatures of roughly 450°C and 600°C. The surfaces were physically characterized by scanning electron microscopy (SEM) and scanning white light interferometry. A week long hFOB 1.19 cell culture was performed using an untreated titanium control to evaluate the suitability of these surfaces for orthopedic implants. Cell health and viability were evaluated by calcein AM live cell staining, MTT assay, and SEM. The results show that helium texturizations promote cellular activity and have no detrimental effect on cell health.