Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum).
Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum).
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发表时间：
1980-10
期刊：
影响因子：
11.2
通讯作者：
A. Pamukcu;Ã. enayyalã §iner;James F. Hatcher;George T. Bryan
中科院分区：
文献类型：
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作者：
A. Pamukcu;Ã. enayyalã §iner;James F. Hatcher;George T. Bryan
白化非近交系断奶雄性和雌性大鼠被喂食基本谷物饮食（第1组）或补充有33%蕨菜[BF（第2组）]或0.1%槲皮素[纯度，> 99%（第3组）]的基本饮食，持续58周。 BF 中以糖苷形式存在的槲皮素和山奈酚（结构相近的类似物）的含量经测定分别为每千克干燥 BF 0.57 和 1.1 g。每只大鼠的估计平均总累积剂量（mmol）为：第 1 组，槲皮素，雄性和雌性 < 0.03；山奈酚，男性和女性 < 0.03；第2组，槲皮素，男性5.8，女性5.2；山奈酚，男性11.9，女性10.8；第3组，槲皮素，男性27.8，女性25.3；山奈酚，男性和女性 < 0.03。饲喂 BF 或槲皮素的大鼠的生长与第 1 组相当，但 24 周后显着 (p < 0.01) 慢于第 1 组。所有组大鼠的平均存活率（周）为：第 1 组，58 +/- 7 (S.D.)；第 1 组，58 +/- 7 (S.D.)；第 1 组，58 +/- 7 (S.D.)；第 2 组，51 +/- 13；第 3 组为 56 +/- 8。尽管喂食 BF 的大鼠往往会因肠道肿瘤引起的肠套叠和梗阻而较早死亡，但它们没有显着差异。分别观察到雄性或雌性大鼠中肠道或膀胱肿瘤的发生率如下：第 1 组，肠道和膀胱，雄性，9 只中有 0 只，雌性，10 只中有 0 只；第2组，肠道，雄性，8只中的7只，雌性，11只中的10只；膀胱，男性8个中6个，女性11个中8个；第3组，肠道，雄性，7只中的6只，雌性，18只中的14只；膀胱，雄性，7 只中的 2 只，雌性，18 只中的 3 只。第 2 组和第 3 组大鼠的 2 个靶器官肿瘤的组织病理学是相同的。喂食槲皮素的大鼠的多发性回肠肿瘤包括：腺瘤，4；纤维腺瘤，7；和腺癌，9（伴有肠系膜转移，3）。 5 例膀胱肿瘤为乳头状或无蒂移行细胞癌。
Albino noninbred weanling male and female rats were fed a basic grain diet (Group 1) or a basic diet supplemented with 33% bracken fern [BF (Group 2)] or 0.1% quercetin [purity, > 99% (Group 3)] for 58 weeks. The quantities of quercetin and kaempferol (a close structural analog) in BF as glycosides were determined to be 0.57 and 1.1 g, respectively, per kg of dried BF. Estimated mean total cumulative doses (mmol) per rat were: Group 1, quercetin, males and females < 0.03; kaempferol, males and females < 0.03; Group 2, quercetin, males 5.8, females 5.2; kaempferol, males 11.9, females 10.8; and Group 3, quercetin, males 27.8, females 25.3; kaempferol, males and females < 0.03. Growth of rats fed BF or quercetin was comparable but significantly (p < 0.01) slower after 24 weeks than that of Group 1. Mean survivals (weeks) of rats of all groups were: Group 1, 58 +/- 7 (S.D.); Group 2, 51 +/- 13; and Group 3, 56 +/- 8. They were not significantly different, although rats fed BF tended to die earlier secondary to intestinal tumor-induced intussusception and obstruction. The following incidences of intestinal or bladder neoplasms in male or female rats, respectively, were observed: Group 1, intestinal and bladder, males, 0 of 9, females, 0 of 10; Group 2, intestinal, males, 7 of 8, females, 10 of 11; bladder, males, 6 of 8, females 8 of 11; Group 3, intestinal, males, 6 of 7, females, 14 of 18; bladder, males, 2 of 7, females, 3 of 18. The histopathology of neoplasms of the 2 target organs was identical for rats of Groups 2 and 3. Multiple ileal intestinal neoplasms of rats fed quercetin included: adenoma, 4; fibroadenoma, 7; and adenocarcinoma, 9 (with mesenteric metastases, 3). The 5 bladder tumors were papillary or sessile transitional cell carcinomas.