Trends in blood pressure in 9 to 11-year-old children in the United Kingdom 1980-2008: the impact of obesity
Trends in blood pressure in 9 to 11-year-old children in the United Kingdom 1980-2008: the impact of obesity
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DOI：
10.1097/hjh.0b013e3283562a6b
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发表时间：
2012-09-01
影响因子：
4.9
通讯作者：
Li, Leah
中科院分区：
文献类型：
--
作者：
Peters, Helen;Whincup, Peter H.;Li, Leah
目的：高血压（BP）是一个主要的公共卫生问题，在英国和世界范围内。虽然英国成年人的BP水平正在下降，但关于儿童BP趋势的公开信息很少，这在儿童肥胖水平上升的背景下尤其令人担忧。我们的目的是确定儿童的BP是否随着时间的推移而变化，以及这种变化是否反映了肥胖症的趋势。方法：我们整理了1980年至2008年在英国进行的7项以人群为基础的BP研究的数据。纳入了白色欧洲血统的儿童（9-11岁，平均10.3岁）。结果：平均收缩压随着时间的推移增加，在男孩和女孩：每年增加0.45毫米汞柱（95%CI：0.43，0.48）的男孩，0.51毫米汞柱（0.49，0.53）的女孩。男孩的平均BMI每年增加0.064 kg/m2（0.060，0.068）;女孩增加0.070 kg/m2（0.065，0.074）;超重/肥胖的患病率分别从5.7%增加到21.1%和从9.7%增加到24.1%。低BMI组和高BMI组儿童的SBP趋势均存在，但低BMI组更为明显; BMI仅解释了男孩SBP升高的15.3%（15.1%，15.6%）和女孩SBP升高的14.9%（14.6%，15.1%）。随着时间的推移，BMI/SBP的相关性似乎变得越来越弱（1984年以来的负相互作用P < 0.001）。DBP的年增长率仅为温和（
Objectives: High blood pressure (BP) is a major public health issue, both in the United Kingdom and worldwide. Although BP levels in UK adults are declining, there is little published information on BP trends in children, a particular concern in the context of the rising levels of childhood adiposity. Our aims are to determine whether BP in children has changed over time and whether the change reflected trends in adiposity.Methods: We collated data from seven population-based BP studies conducted in the United Kingdom between 1980 and 2008. Children of white European origin were included (9-11 years, mean 10.3 years). Adjustments were made to account for differences in mean ages, BP devices and cuff sizes used in different studies.Results: Mean SBP increased over time both in boys and girls: annual increases were 0.45 mmHg (95% CI: 0.43, 0.48) for boys; 0.51 mmHg (0.49, 0.53) for girls. Mean BMI increased by 0.064 kg/m(2) (0.060, 0.068) per year for boys; 0.070 kg/m(2) (0.065, 0.074) for girls; the prevalence of overweight/obesity increased from 5.7 to 21.1% and from 9.7 to 24.1%, respectively. The SBP trends occurred both in children with low and high BMI, but were more marked in low BMI group; BMI explained only 15.3% (15.1%, 15.6%) of increases in SBP for boys and 14.9% (14.6%, 15.1%) for girls. The BMI/SBP association appeared to become weaker over time (P < 0.001 for negative interaction from 1984). There was only a modest annual increase in DBP (