The impact of visceral fat in nonalcoholic fatty liver disease: cross-sectional and longitudinal studies
The impact of visceral fat in nonalcoholic fatty liver disease: cross-sectional and longitudinal studies
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DOI：
10.1007/s00535-007-2107-z
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发表时间：
2007-11-01
影响因子：
6.3
通讯作者：
Senda, Miho
中科院分区：
文献类型：
--
作者：
Koda, Masahiko;Kawakami, Manri;Senda, Miho
背景。非酒精性脂肪性肝病在世界范围内呈上升趋势，其与肥胖和代谢综合征的关系引起了人们的关注。本研究的目的是通过横断面和纵向研究阐明内脏脂肪堆积在肝脂肪变性中的作用。方法。我们在横断面研究中招募了125名患者，在纵向研究中招募了28名患者，并检查了内脏和皮下脂肪厚度、肝脏脂肪变性评分和生化参数。在纵向研究中，研究了体重变化对脂肪分布和肝脏脂肪变性的影响。结果。横断面研究中，肝脂肪变性严重程度与体重指数、内脏脂肪厚度、血清白蛋白、谷丙转氨酶（ALT）、胆碱酯酶、空腹胰岛素及胰岛素抵抗稳态模型评估呈正相关。ALT、内脏脂肪厚度和血清白蛋白是肝脂肪变性的独立因素。在纵向研究中，内脏脂肪厚度随体重变化而波动密切，多因素分析表明内脏脂肪厚度与肝脏脂肪变性的变化关系最强。结论。内脏脂肪是肝脂肪变性发生的最重要因素。超声可方便、无创、反复测量内脏脂肪厚度，用于评估中心性肥胖和监测非酒精性脂肪性肝病的治疗效果。
Background. Nonalcoholic fatty liver disease is increasing worldwide, and attention is being paid to its association with obesity and metabolic syndrome. The aim of this study was to elucidate the role of visceral fat accumulation in hepatic steatosis by cross-sectional and longitudinal studies. Methods. We enrolled 125 patients in a cross-sectional study and 28 patients in a longitudinal study and examined visceral and subcutaneous fat thickness, hepatic steatosis score, and biochemical parameters. In the longitudinal study, the influence of weight change on fat distribution and hepatic steatosis was investigated. Results. In the cross-sectional study, the severity of hepatic steatosis showed a significant positive correlation with body mass index, visceral fat thickness, serum albumin, alanine aminotransferase (ALT), cholinesterase, fasting insulin, and the homeostasis model assessment of insulin resistance. ALT, visceral fat thickness, and serum albumin were independent factors for hepatic steatosis. In the longitudinal study, visceral fat thickness fluctuated closely with changes in body weight, and had the strongest relationship with the change of hepatic steatosis by multivariate analysis. Conclusions. Visceral fat was the most important factor for the development of hepatic steatosis. Visceral fat thickness can be measured by sonography easily, noninvasively, and repeatedly for assessment of central obesity and monitoring of the efficacy of treatment of nonalcoholic fatty liver disease.