Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis
Chaiqin Chengqi Decoction decreases IL-6 levels in patients with acute pancreatitis
复制标题
柴芩承气汤降低急性胰腺炎患者IL-6水平
DOI：
10.1631/jzus.b1000406
复制
发表时间：
2011-12-01
影响因子：
5.1
通讯作者：
Zhou, Zong-guang
中科院分区：
文献类型：
--
作者：
Wang, Ling;Li, Yuan;Zhou, Zong-guang
为探讨中药柴芩承气汤对急性胰腺炎（AP）患者血清细胞因子的影响，收集107例AP患者发病48 h内及治疗第10天的外周血标本。从20名健康个体收集对照样品。血清促炎细胞因子肿瘤坏死因子-α采用Luminex 100系统检测急性胰腺炎患者血清中TNF-α、IL-6、IL-10、IL-1 β受体拮抗剂（IL-1 ra）水平，结果重症急性胰腺炎（SAP）患者血清IL-6、IL-1 ra水平明显高于轻度急性胰腺炎（MAP）患者，SAP组IL-10水平明显低于MAP组。CQCQD治疗后，促炎细胞因子IL-6水平明显降低（P < 0.05），尤以SAP组为甚（25/36，P < 0.05）。CQCQD治疗后血清IL-6水平降低，SAP患者住院时间明显缩短（P < 0.05），CQCQD治疗后血清IL-6水平降低。
In this paper, we investigated the effect of the traditional Chinese medicine Chaiqin Chengqi Decoction (CQCQD) on serum cytokines in acute pancreatitis (AP) patients.Peripheral blood samples from 107 AP patients were collected within the first 48 h of AP onset and on the 10th day of CQCQD treatment. Control samples were collected from 20 healthy individuals. Serum proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), and anti-inflammatory cytokines IL-10 and IL-1 beta receptor antagonist (IL-1ra) were examined using the Luminex 100 system.Within the first 48 h of AP onset, IL-6 and IL-1ra levels in severe AP (SAP) patients were significantly higher than those in mild AP (MAP) patients, but IL-10 levels in SAP patients were significantly lower than those in MAP patients. Proinflammatory cytokine IL-6 was significantly decreased after CQCQD treatment (P < 0.05), especially in SAP patients (n=25 of 36, P < 0.05). The hospitalization time of SAP patients was shortened significantly when serum IL-6 decreased after CQCQD treatment (P < 0.05).CQCQD decreased proinflammatory cytokine IL-6 levels in AP patients.