Phthalate exposure and human semen parameters
Phthalate exposure and human semen parameters
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DOI：
10.1097/00001648-200305000-00005
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发表时间：
2003-05-01
期刊：
影响因子：
5.4
通讯作者：
Hauser, R
中科院分区：
文献类型：
--
作者：
Duty, SM;Silva, MJ;Hauser, R
背景。科学界和公众对常用化学物质（包括邻苯二甲酸盐）感到担忧，这些化学物质与实验动物的生殖毒性有关，并且具有激素活性。人们通过饮食、消费品和医疗设备接触邻苯二甲酸盐。本研究探讨了邻苯二甲酸盐的环境水平是否与人类精液质量的改变有关。方法。我们招募了 168 名男性，他们是生育能力低下的夫妇，他们在 2000 年 1 月至 2001 年 4 月期间到马萨诸塞州总医院男科实验室进行精液分析。精液参数根据 1999 年世界卫生组织精子浓度参考值进行二分（
Background. There is scientific and public concern about commonly used chemicals, including phthalates, that are associated with reproductive toxicity in laboratory animals and are hormonally active. People are exposed to phthalates through diet, consumer products and medical devices. The present study explored whether environmental levels of phthalates are associated with altered semen quality in humans.Methods. We recruited 168 men who were part of subfertile couples and who presented to the Massachusetts General Hospital andrology laboratory for semen analysis between January 2000 and April 2001. Semen parameters were dichotomized based on 1999 World Health Organization reference values for sperm concentration (