LATENT HERPES SIMPLEX VIRUS IN THE CENTRAL NERVOUS SYSTEM OF RABBITS AND MICE
LATENT HERPES SIMPLEX VIRUS IN THE CENTRAL NERVOUS SYSTEM OF RABBITS AND MICE
复制标题
兔和小鼠中枢神经系统中的潜伏单纯疱疹病毒
DOI：
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发表时间：
1973
影响因子：
15.3
通讯作者：
J. G. Stevens
中科院分区：
文献类型：
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作者：
F. Knotts;M. L. Cook;J. G. Stevens
单纯疱疹病毒(HSV)1型在小鼠和兔的中枢神经系统中诱导长期潜伏感染。兔角膜接种病毒后的脑干和小鼠后足垫感染的脊髓中均有感染。在这些动物中，传染性病毒不能通过直接从组织中分离出来，只有在组织作为体外器官培养物保存后才能检测到。
Herpes simplex virus (HSV) type 1 induces a long-standing latent infection in the central nervous system of mice and rabbits. The infection was extablished in the brain stems of rabbits after corneal inoculation of the virus, and in the spinal cords of mice after rear footpad infection. In these animals, infectious virus could not be recovered by direct isolation from tissues; it was detected only after the tissues were maintained as organ cultures in vitro.