T-cell lymphoma complicated by myelofibrosis : report of three cases and review of literature
T-cell lymphoma complicated by myelofibrosis : report of three cases and review of literature
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T细胞淋巴瘤并发骨髓纤维化三例报告并文献复习
DOI：
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发表时间：
2016
期刊：
影响因子：
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通讯作者：
M. Noguchi
中科院分区：
文献类型：
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作者：
Y. Sekiguchi;Syuichi Shirane;H. Takizawa;M. Wakabayashi;K. Sugimoto;S. Tomita;H. Izumi;N. Nakamura;T. Sawada;Y. Ohta;N. Komatsu;M. Noguchi
原发性骨髓纤维化 (MF) 是一种罕见的癌性疾病，会破坏正常的血细胞生成并导致疤痕组织在骨髓内积聚。 MF 并发恶性淋巴瘤很少见，其病因通常仍不清楚，但与原发性 MF 一样，其发病机制可能与增殖的巨核细胞、单核细胞和组织细胞产生的细胞因子有关。我们经历了三例外周T细胞淋巴瘤（PTCL）并发MF的病例。在每个病例中，入院时均未发现中枢神经系统浸润的证据；然而，存在骨髓浸润。我们通过淋巴结和骨髓免疫染色对这三名患者的恶性细胞产生细胞因子的时间顺序进行了分析。治疗前从淋巴结和骨髓取样的恶性细胞细胞因子染色呈阳性：病例1为血小板衍生生长因子（PDGF）和肿瘤坏死因子-α（TNF-α）；情况2中的PDGF；病例 3 中的 PDGF、TNF-α 和转化生长因子-β。这些细胞因子被认为是每个病例中 MF 的原因。经文献检索，目前已报道T细胞淋巴瘤并发MF的病例16例（包括我们的3例）。总结了这些报告中给出的恶性细胞产生细胞因子的数据。关于细胞因子在 MF 发展中的作用仍有许多待澄清。因此，我们计划对 PTCL 和恶性淋巴瘤（包括 MF 并发和非 MF 并发病例）进行血清细胞因子检查和细胞因子免疫染色。
Primary myelofibrosis (MF) is a rare cancerous condition that disrupts normal blood cell production and causes scar tissue to accumulate within the bone marrow. MF complicating malignant lymphoma is rare and its cause often remains unknown, but, like primary MF, its pathogenesis is likely related to cytokines produced by proliferating megakaryocytes, monocytes, and histiocytes. We have experienced three cases of peripheral T-cell lymphoma (PTCL) complicated by MF. In each case, no evidence of central nervous system infiltration was found on admission; however, bone marrow infiltration was present. We carried out a chronological analysis of the cytokine production by malignant cells in these three patients by means of lymph node and bone marrow immunostaining. Malignant cells from lymph nodes and bone marrow sampled before treatment stained positive for cytokines: platelet-derived growth factor (PDGF) and tumor necrosis factor-α (TNF-α) in case 1; PDGF in case 2; and PDGF, TNF-α, and transforming growth factor-β in case 3. These cytokines were considered to have been the cause of MF in each case. A literature search indicated that 16 cases of T-cell lymphoma complicated by MF (including our three cases) have been reported to date. Data on cytokine production by malignant cells given in these reports are summarized. Much remains to be clarified concerning the role of cytokines in the development of MF. Consequently, we plan to carry out chronological examinations of cytokines in the serum and immunostaining for cytokines in cases of PTCL and malignant lymphoma, both those complicated and not complicated by MF.
外周 T 细胞淋巴瘤与骨髓纤维化伴血浆转化生长因子-β1 升高。
DOI：
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发表时间：
2005
期刊：
Leuk Lymphoma. 46 4
影响因子：
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作者：
Ito K;Nakazato T;et al.;Takedatsu.H;Hashiguchi M;Takedatsu. H;Mori. T;Takedatsu. H;Ohtsubo K;Okabe s et al.;Tauchi t et al.;Okabe s et al.
通讯作者：
Okabe s et al.