Evaluation of Biochemical Parameters and Local and Systemic Levels of Osteoactive and B-Cell Stimulatory Factors in Gestational Diabetes in the Presence or Absence of Gingivitis
Evaluation of Biochemical Parameters and Local and Systemic Levels of Osteoactive and B-Cell Stimulatory Factors in Gestational Diabetes in the Presence or Absence of Gingivitis
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DOI：
10.1902/jop.2014.140444
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发表时间：
2015-03-01
影响因子：
4.3
通讯作者：
Buduneli, Nurcan
中科院分区：
文献类型：
--
作者：
Gumus, Pinar;Ozcaka, Ozgan;Buduneli, Nurcan
背景：妊娠期糖尿病（GDM）被定义为不同的葡萄糖耐受不良，在怀孕期间首次发病或识别。本研究评估了 GDM 与牙龈炎之间可能存在关联的临床和生化参数。方法：该研究共纳入 167 名怀孕女性。 101 名女性患有 GDM，66 名女性没有 GDM。根据牙龈炎症的存在或不存在创建亚组。在每颗牙齿的四个部位记录牙菌斑指数、探诊出血和探诊深度。通过酶联免疫吸附测定测定血清、唾液和龈沟液 (GCF) 中白细胞介素 (IL)-6、IL-8、核因子 kappa B 配体可溶性受体激活剂 (sRANKL)、骨保护素 (OPG)、B 细胞激活因子 (BAFF) 和增殖诱导配体 (APRIL) 的水平。数据通过Kruskal-Wallis和Mann-Whitney U检验以及Spearman相关分析进行分析。结果：GDM组的年龄和人体测量指数高于非GDM组（P
Background: Gestational diabetes mellitus (GDM) is defined as varying glucose intolerance, with first onset or recognition in pregnancy. This study evaluates clinical and biochemical parameters in a possible association between GDM and gingivitis.Methods: A total of 167 pregnant females was included in the study. There were 101 females with GDM and 66 females without GDM. Subgroups were created according to the presence or absence of gingival inflammation. Plaque index, bleeding on probing, and probing depth were recorded at four sites per tooth. Serum, saliva, and gingival crevicular fluid (GCF) levels of interleukin (IL)-6, IL-8, soluble receptor activator of nuclear factor-kappa B ligand (sRANKL), osteoprotegerin (OPG), B-cell activating factor (BAFF), and a proliferation-inducing ligand (APRIL) were determined by enzyme-linked immunosorbent assay. Data were analyzed by Kruskal-Wallis and Mann-Whitney U tests and Spearman correlation analysis.Results: Age and anthropometric indices were higher in the GDM than non-GDM group (P