Impulsive choice and anxiety-like behavior in adult rats exposed to chronic intermittent ethanol during adolescence and adulthood.
Impulsive choice and anxiety-like behavior in adult rats exposed to chronic intermittent ethanol during adolescence and adulthood.
复制标题
DOI：
10.1016/j.bbr.2014.02.019
复制
发表时间：
2014-06-01
影响因子：
2.7
通讯作者：
Semenova S
中科院分区：
文献类型：
--
作者：
Mejia-Toiber J;Boutros N;Markou A;Semenova S
青春期和成年期的酗酒可能对大脑产生不同的长期影响。我们研究了青春期和成年期慢性间歇性乙醇（CIE）暴露对冲动和焦虑样行为的长期影响。在出生后第28 - 53天和第146 - 171天，将青春期（酒精暴露）和成年（成年暴露）大鼠分别暴露于CIE/水，并分别在第181 - 184天和第271 - 274天进行为期4天的乙醇/水狂欢。在退出CIE和4天的暴饮暴食暴露期间，分别在光增强惊吓（LPS）和声学惊吓（ASR）程序中测量焦虑样行为和唤醒。在基线和乙醇挑战后，在延迟折扣任务（DDT）中评估冲动选择。独立于年龄，ASR和LPS下降，在退出CIE曝光。与此相反，LPS增加成年暴露，但不暴露，大鼠在撤出4天的酒精狂欢。CIE暴露对基线时大延迟奖励的偏好没有影响，与年龄无关。DDT收购期间，CIE暴露，与水暴露的大鼠相比，省略了更多的反应，独立于年龄，表明CIE引起的认知过程的中断。乙醇的挑战降低了偏好的大奖励在年轻的酒精暴露的大鼠，但没有影响在老年人暴露的大鼠独立于以前的CIE/水暴露。总之，目前的研究表明，CIE撤退引起的焦虑和觉醒的减少是没有年龄特异性的。CIE暴露对基线冲动选择没有长期影响。随后的乙醇暴露对冲动性（暴露于乙醇的年轻大鼠冲动性增加）和焦虑样行为（暴露于乙醇的老年大鼠焦虑样行为增加）产生了年龄依赖性影响。
Binge drinking during adolescence and adulthood may have differential long-term effects on the brain. We investigated the long-term effects of chronic intermittent ethanol (CIE) exposure during adolescence and adulthood on impulsivity and anxiety-like behavior. Adolescent (adolescent-exposed) and adult (adult-exposed) rats were exposed to CIE/water on postnatal days (PND) 28-53 and PND146-171, respectively, and a 4-day ethanol/water binge on PND181-184 and PND271-274, respectively. During withdrawal from CIE and 4-day binge exposures, anxiety-like behavior and arousal were measured in the light-potentiated startle (LPS) and the acoustic startle (ASR) procedures, respectively. Impulsive choice was evaluated in the delay discounting task (DDT) at baseline and after ethanol challenges. Independent of age, ASR and LPS were decreased during withdrawal from CIE exposure. In contrast, LPS was increased in adult-exposed, but not adolescent-exposed, rats during withdrawal from the 4-day ethanol binge. CIE exposure had no effect on preference for the large delayed reward at baseline, independent of age. During DDT acquisition, CIE-exposed, compared with water-exposed rats, omitted more responses, independent of age, suggesting CIE-induced disruption of cognitive processes. Ethanol challenges decreased preference for the large reward in younger adolescent-exposed rats but had no effect in older adult-exposed rats independent of previous CIE/water exposure. Taken together, the present studies demonstrate that CIE withdrawal-induced decreases in anxiety and arousal were not age-specific. CIE exposure had no long-term effects on baseline impulsive choice. Subsequent ethanol exposure produced age-dependent effects on impulsivity (increased impulsivity in younger adolescent-exposed rats) and anxiety-like behavior (increased anxiety-like behavior in older adult-exposed rats).