The rise and fall of basal bodies in the nematode Caenorhabditis elegans.
The rise and fall of basal bodies in the nematode Caenorhabditis elegans.
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作者：
Nechipurenko IV;Sengupta P
线虫是一种广泛用于研究中心粒和纤毛生物学的遗传模式生物。线虫中只有感觉神经元是纤毛的；这些神经元中形态多样的纤毛是由位于树突末端的基本体形成的。线虫中心粒由一个中心管组成，中心管由9个单线微管组成对称阵列。这些单线微管在感觉神经元的一个子集中重塑，形成基底体的双线微管。在纤毛发生开始后，基底体的中央管而不是外部中心粒壁退化。最近对基底体结构和重塑的超微结构特征为进一步研究基底体发生、重塑和细胞内定位的不同方面的机制奠定了基础。
The free-living nematode, Caenorhabditis elegans, is a widely used genetic model organism for investigations into centriole and cilia biology. Only sensory neurons are ciliated in C. elegans; morphologically diverse cilia in these neurons are nucleated by basal bodies located at the dendritic endings. C. elegans centrioles comprise a central tube with a symmetric array of nine singlet microtubules. These singlet microtubules remodel in a subset of sensory neurons to form the doublet microtubules of the basal bodies. Following initiation of ciliogenesis, the central tube, but not the outer centriole wall, of the basal body degenerates. Recent ultrastructural characterization of basal body architecture and remodeling have laid the foundation for future studies into mechanisms underlying different aspects of basal body genesis, remodeling, and intracellular positioning.