Subconcussive Head Impact Exposure and White Matter Tract Changes over a Single Season of Youth Football
Subconcussive Head Impact Exposure and White Matter Tract Changes over a Single Season of Youth Football
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DOI：
10.1148/radiol.2016160564
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发表时间：
2016-12-01
期刊：
影响因子：
19.7
通讯作者：
Maldjian, Joseph A.
中科院分区：
文献类型：
--
作者：
Bahrami, Naeim;Sharma, Dev;Maldjian, Joseph A.
目的：研究由一个单一的青春期引起的亚震荡冲击的影响（年龄范围，8-13岁）足球的变化，在特定的白色物质（WM）束检测与扩散张量成像在临床诊断concussions.Materials和方法：头部撞击数据记录使用头部撞击遥测系统和量化的组合概率风险加权累积曝光（RWE CP）。对25名男性参与者进行了特定WM束的季节性各向异性分数（FA）变化评估：下额枕束（IFOF），下纵束和上级纵束（SLF）。纤维束分为一个中央核心和两个纤维末端。此外，还研究了全纤维、中心纤维和纤维末端的FA季节性变化与RWE CP的关系。结果：RWEcp与纤维束FA在整个季节内的变化呈显著的线性关系，RWEcp与FA在整个季节内的变化呈显著的线性关系左侧IFOF的核心（R-2 = 0.3649; P = 0.007）和末端（R-2 = 0.5666; P <0.001）。观察到右侧SLF有统计学显著性趋势（P = .08）。还观察到右侧SLF末端FA降低与RWE CP之间存在统计学显著相关性（R-2 = 0.2893; P = 0.028）。本研究发现，头部撞击暴露与WM和灰质交界处左侧IFOF和右侧SLF终末的整体、核心和终末FA值的变化有统计学意义的相关性，在没有临床诊断为脑震荡的情况下(C)RSNA，2016
Purpose: To examine the effects of subconcussive impacts resulting from a single season of youth (age range, 8-13 years) football on changes in specific white matter (WM) tracts as detected with diffusion-tensor imaging in the absence of clinically diagnosed concussions.Materials and Methods: Head impact data were recorded by using the Head Impact Telemetry system and quantified as the combined-probability risk-weighted cumulative exposure (RWE CP). Twenty-five male participants were evaluated for seasonal fractional anisotropy (FA) changes in specific WM tracts: the inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus, and superior longitudinal fasciculus (SLF). Fiber tracts were segmented into a central core and two fiber terminals. The relationship between seasonal FA change in the whole fiber, central core, and the fiber terminals with RWE CP was also investigated. Linear regression analysis was conducted to determine the association between RWE CP and change in fiber tract FA during the season.Results: There were statistically significant linear relationships between RWEcp and decreased FA in the whole (R-2 = 0.433; P = .003), core (R-2 = 0.3649; P =.007), and terminals (R-2 = 0.5666; P < .001) of left IFOF. A trend toward statistical significance (P = .08) in right SLF was observed. A statistically significant correlation between decrease in FA of the right SLF terminal and RWE CP was also observed (R-2 = 0.2893; P = .028).Conclusion: This study found a statistically significant relationship between head impact exposure and change of FA value of whole, core, and terminals of left IFOF and right SLF's terminals where WM and gray matter intersect, in the absence of a clinically diagnosed concussion. (C) RSNA, 2016