CYTOTOXIC T-LYMPHOCYTE PRECURSOR FREQUENCY DOES NOT CORRELATE WITH EITHER THE INCIDENCE OR SEVERITY OF GRAFT-VERSUS-HOST DISEASE AFTER MATCHED UNRELATED DONOR BONE-MARROW TRANSPLANTATION
CYTOTOXIC T-LYMPHOCYTE PRECURSOR FREQUENCY DOES NOT CORRELATE WITH EITHER THE INCIDENCE OR SEVERITY OF GRAFT-VERSUS-HOST DISEASE AFTER MATCHED UNRELATED DONOR BONE-MARROW TRANSPLANTATION
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DOI：
10.1097/00007890-199403150-00008
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发表时间：
1994-03-15
期刊：
影响因子：
6.2
通讯作者：
FARRELL, C
中科院分区：
文献类型：
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作者：
FUSSELL, ST;DONNELLAN, M;FARRELL, C
与HLA相同的同胞供体相比，来自匹配的无关供体或不匹配的家庭成员的BMT与移植物抗宿主病（GVHD）的风险增加相关。本研究包括17例患者，均接受HLA-A，B，DR匹配的非血缘供者的未经处理的骨髓。在移植前在供体中估计患者特异性CTLp频率。然后将CTLp频率与移植后患者经历的GVHD的发生率和严重程度进行比较。统计学分析显示供体前体频率与移植后发生临床显著急性GVHD的患者之间无相关性（X（2）=1.16）。本研究提示，临床选择最适合的非血缘相合供者进行骨髓移植时，应谨慎考虑CTLp频率的影响，CTLp频率与非血缘相合供者骨髓移植后GVHD的发生率和严重程度均无相关性。
BMT from matched unrelated donors or mismatched family members is associated with an increased risk of graft-versus-host disease (GVHD) compared with HLA- identical sibling donors. It has been suggested that the level of patient-specific CTL precursors (CTLp) present in matched unrelated donors correlates with the incidence and severity of GVHD after BRIT This study group consisted of 17 patients who all received unmanipulated bone marrow from an HLA-A,B,DR-matched unrelated donor. Patient-specific CTLp frequencies were estimated in the donor before transplant. The CTLp frequencies were then compared with the incidence and severity of GVHD experienced by the patient after transplantation. Statistical analysis revealed no correlation between donor precursor frequencies and the patient developing clinically significant acute GVHD after transplantation (X(2)=1.16). This study suggests that caution should be used before the inclusion of the CTLp frequency result in the clinical decision of selecting the most suitable matched unrelated donor for BMT.CTLp frequency does not correlate with either the incidence or severity of GVHD after matched unrelated donor BMT.