Role of Hyperinsulinemia in Increased Risk of Prostate Cancer: A Case Control Study from Kathmandu Valley
Role of Hyperinsulinemia in Increased Risk of Prostate Cancer: A Case Control Study from Kathmandu Valley
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DOI：
10.7314/apjcp.2014.15.2.1031
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发表时间：
2014-01-01
影响因子：
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通讯作者：
Bhatta, Bibek
中科院分区：
文献类型：
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作者：
Pandeya, Dipendra Raj;Mittal, Ankush;Bhatta, Bibek
目的：探讨高血糖和高胰岛素血症对前列腺癌危险性的影响。材料与方法：这项基于医院的研究使用从2011年12月31日至2013年10月31日期间尼泊尔加德满都三级护理医院生化科保存的登记簿中检索的数据进行。收集的变量包括年龄、血清胆固醇、血清钙、PSA、空腹血糖、血清胰岛素。使用Excel 2003，R 2.8.0，社会科学统计软件包（SPSS）Windows 16.0版（SPSS Inc;芝加哥，IL，美国）和EPI Info 3.5.1 Windows版，通过描述性统计和假设检验进行分析。结果：125例受试者中，25例为前列腺癌，100例为健康对照。前列腺癌患者的空腹血糖平均值为95.5 mg/dl，空腹血浆胰岛素平均值为5.78 μ U/ml（p值：0.0001*）。空腹胰岛素水平μ U/ml被分类为从2.75至4.10至6.10 μ U/ml的不同范围。空腹胰岛素水平福尔斯的前列腺癌病例的最大数量落在>6.10 μ U/ml的范围内。与空腹胰岛素水平（>6.10 μ U/ml）相比，最高胰岛素水平（>6.10 μ U/ml）与前列腺癌风险相关2.55倍（
Aim: To investigate the effect of hyperglycemia and hyperinsulinemia on prostate cancer risk. Materials and Methods: This hospital based study was carried out using data retrieved from the register maintained in the Department of Biochemistry of a tertiary care hospital of Kathmandu, Nepal between 31st December, 2011 and 31st October, 2013. The variables collected were age, serum cholesterol, serum calcium, PSA, fasting blood glucose, serum insulin. Analysis was performed by descriptive statistics and testing of hypothesis using Excel 2003, R 2.8.0, Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. Results: Of the total 125 subjects enrolled in our present study, 25 cases were of PCa and 100 were healthy controls. The mean value of fasting plasma glucose was 95.5 mg/dl in cases of prostatic carcinoma and the mean value of fasting plasma insulin was 5.78 mu U/ml (p value: 0.0001*). The fasting insulin levels mu U/ml were categorized into the different ranges starting from 2.75 to 4.10 to 6.10 mu U/ml. The maximum number of cases of prostatic carcinoma of fasting insulin levels falls in range of >6.10 mu U/ml. The highest insulin levels (>6.10 mu U/ml) were seen to be associated with an 2.55 fold risk of prostatic carcinoma when compared with fasting insulin levels of (