Quantum cascade laser-based carbon monoxide detection on a second time scale from human breath
Quantum cascade laser-based carbon monoxide detection on a second time scale from human breath
复制标题
DOI：
10.1007/s00340-005-2124-7
复制
发表时间：
2006-03-01
影响因子：
2.1
通讯作者：
Harren, FJM
中科院分区：
文献类型：
--
作者：
Moeskops, BWM;Naus, H;Harren, FJM
我们提出了三种不同的检测方案测量一氧化碳（CO）在直接吸收使用热电冷却，分布反馈脉冲量子级联（qc）激光器工作在2176和2183 cm（-1）。在2176.2835cm（-1）处，激光辐射与CO的强R（8）1振转跃迁有重叠。首先，利用长激光脉冲qc激光器的频率啁啾，在3 Hz的采集速率下获得了1.2 × 10 ~（-5）cm ~（-1）的最小可探测吸收。此外，采用短激光脉冲和慢频率扫描，报告了最小可检测吸收8.2 x 10（-7）cm（-1），采集时间为60 s。最后，开发了一种新的幅度调制技术，以便于实时测量呼出气体中的CO。该检测器的应用，以检测CO在一个单一的呼吸作为一个潜在的非侵入性诊断工具。
We present three different detection schemes for measuring carbon monoxide (CO) in direct absorption using a thermoelectrically cooled, distributed-feedback pulsed quantum cascade (qc) laser operating between 2176 and 2183 cm(-1). The laser emission has overlap with the strong R(8)1 rovibrational transition in CO at 2176.2835 cm(-1). Firstly, by utilizing the frequency chirp of the qc-laser with long laser pulses, a minimal detectable absorption of 1.2 x 10(-5) cm(-1) is achieved at an acquisition rate of 3 Hz. Additionally, with short laser pulses and slow frequency scanning a minimal detectable absorption 8.2 x 10(-7) cm(-1) is reported, with an acquisition time of 60 s. Finally, a novel amplitude modulation technique is developed to facilitate real-time measurement of CO in exhaled air. The application of this detector to detection of CO in a single breath as a potential non-invasive diagnostic tool is shown.