GTPASE INHIBITING MUTATIONS ACTIVATE THE ALPHA-CHAIN OF GS AND STIMULATE ADENYLYL CYCLASE IN HUMAN PITUITARY-TUMORS
GTPASE INHIBITING MUTATIONS ACTIVATE THE ALPHA-CHAIN OF GS AND STIMULATE ADENYLYL CYCLASE IN HUMAN PITUITARY-TUMORS
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DOI：
10.1038/340692a0
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发表时间：
1989-08-31
期刊：
影响因子：
64.8
通讯作者：
VALLAR, L
中科院分区：
文献类型：
--
作者：
LANDIS, CA;MASTERS, SB;VALLAR, L
一种分泌生长激素的人垂体瘤携带抑制G蛋白α链αs的GT3活性的体细胞突变。腺苷酸环化酶的激活绕过了细胞对营养激素的正常需求。在推定的gsp癌基因中取代的氨基酸确定了水解GTP的内在能力所需的G蛋白α链的结构域。该结构域可能作为单独的GTP酶激活蛋白的内置对应部分，这些单独的GTP酶激活蛋白是由小GTP结合蛋白如p21ras水解GTP所需的。
A subset of growth hormone-secreting human pituitary tumours carries somatic mutations that inhibit GTPase activity of a G protein α chain, αs. The resulting activation of adenylyl cyclase bypasses the cells' normal requirement for trophic hormone. Amino acids substituted in the putative gsp oncogene identify a domain of G protein α-chains required for intrinsic ability to hydrolyse GTP. This domain may serve as a built-in counter-part of the separate GTPase-activating proteins required for GTP hydrolysis by small GTP-binding proteins such as p21ras.