Pulse wave imaging of a stenotic artery model with plaque constituents of different stiffnesses: Experimental demonstration in phantoms and fluid-structure interaction simulation.
Pulse wave imaging of a stenotic artery model with plaque constituents of different stiffnesses: Experimental demonstration in phantoms and fluid-structure interaction simulation.
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DOI：
10.1016/j.jbiomech.2023.111502
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发表时间：
2023-02
影响因子：
2.4
通讯作者：
N. Mobadersany;Nirvedh H. Meshram;Paul Kemper;C. V. Sise;Grigorios M. Karageorgos;Pengcheng Liang;G. Ateshian;E. Konofagou
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文献类型：
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作者：
N. Mobadersany;Nirvedh H. Meshram;Paul Kemper;C. V. Sise;Grigorios M. Karageorgos;Pengcheng Liang;G. Ateshian;E. Konofagou
与较软成分相关的易损斑块可能破裂，释放血栓栓塞到脑内较小的血管，从而引起缺血性中风。脉冲波成像（PWI）是一种基于超声的方法，它允许脉冲波可视化，同时沿着动脉壁绘制区域脉冲波速度（PWV），以推断下壁的顺应性。PWI的一个潜在应用是对斑块的机械特性进行无创评估，以研究其易损性。在这项研究中，通过计算模拟和验证模型中的PWI来研究狭窄血管中PWV估计的准确性，以评估这种评估未来卒中风险的模式。设计并制作了具有不同硬度斑块成分的聚乙烯醇（PVA）模型来模拟狭窄动脉，并描述了该模型的制作工艺。在一个狭窄体模型中进行了有限元流固耦合模拟，该模型与实验体的几何形状和参数相匹配。通过跟踪幻壁的峰值膨胀加速度来估计PWV。在实验过程中，PWI分别在软、中、硬斑块材料中获得2.57 ms−1、3.41 ms−1和4.48 ms−1的pwv。在计算模拟中，软、中、硬斑块材料的pwv分别为2.10 ms−1、3.33 ms−1和4.02 ms−1。这些结果表明，与计算模拟相比，PWI可以有效地区分斑块的力学性质。
Vulnerable plaques associated with softer components may rupture, releasing thrombotic emboli to smaller vessels in the brain, thus causing an ischemic stroke. Pulse Wave Imaging (PWI) is an ultrasound-based method that allows for pulse wave visualization while the regional pulse wave velocity (PWV) is mapped along the arterial wall to infer the underlying wall compliance. One potential application of PWI is the non-invasive estimation of plaque’s mechanical properties for investigating its vulnerability. In this study, the accuracy of PWV estimation in stenotic vessels was investigated by computational simulation and PWI in validation phantoms to evaluate this modality for assessing future stroke risk. Polyvinyl alcohol (PVA) phantoms with plaque constituents of different stiffnesses were designed and constructed to emulate stenotic arteries in the experiment, and the novel fabrication process was described. Finite-element fluid–structure interaction simulations were performed in a stenotic phantom model that matched the geometry and parameters of the experiment in phantoms. The peak distension acceleration of the phantom wall was tracked to estimate PWV. PWVs of 2.57 ms−1, 3.41 ms−1, and 4.48 ms−1were respectively obtained in the soft, intermediate, and stiff plaque material in phantoms during the experiment using PWI. PWVs of 2.10 ms−1, 3.33 ms−1, and 4.02 ms−1were respectively found in the soft, intermediate, and stiff plaque material in the computational simulation. These results demonstrate that PWI can effectively distinguish the mechanical properties of plaque in phantoms as compared to computational simulation.