Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application
Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application
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DOI：
10.1016/j.nano.2013.10.003
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发表时间：
2014-04-01
影响因子：
5.4
通讯作者：
Minetti, Giampaolo
中科院分区：
文献类型：
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作者：
Achilli, Cesare;Grandi, Stefania;Minetti, Giampaolo
硼中子俘获疗法（BNCT）是一种放射治疗方法，其原理是含B-10的药物在肿瘤中积聚，随后用低能中子照射，使B-10衰变成Li-7和α粒子，从而导致肿瘤细胞死亡。 BNCT 的有效性受到所用含硼化合物的低输送和积累的限制。在此，我们报告了 BPO4 纳米颗粒 (NP) 作为 BNCT 的新型可能替代药物的开发和表征。使用成熟血细胞（红细胞、中性粒细胞和血小板）和造血祖细胞模型对 BPO4 NP 生物相容性进行了广泛分析。对肿瘤性结肠癌细胞和骨肉瘤细胞系进行了时间和浓度依赖性细胞毒性研究。使用叶酸对 BPO4 进行功能化，旨在改善肿瘤细胞的摄取，似乎可以有效限制 NP 对分析的血液成分的不良影响。来自临床编辑：硼中子捕获疗法 (BNCT) 是一种放射治疗方式，基于含 B-10 的药物的积累和随后用低能中子的照射，诱导 B-10 衰变到 Li-7 和一个 a 粒子，导致肿瘤细胞死亡。该作者团队报告了一种叶酸功能化的 BPO4 纳米颗粒，与传统的 BNCT 方法相比，其特性得到了改善，正如在肿瘤细胞系中所证明的那样，并希望能够进行转化性人类研究。 (C) 2014 Elsevier Inc. 保留所有权利。
Boron neutron capture therapy (BNCT) is a radiotherapy treatment based on the accumulation in the tumor of a B-10-containing drug and subsequent irradiation with low energy neutrons, which bring about the decay of B-10 to Li-7 and an a particle, causing the death of the neoplastic cell. The effectiveness of BNCT is limited by the low delivery and accumulation of the used boron-containing compounds. Here we report the development and the characterization of BPO4 nanoparticles (NPs) as a novel possible alternative drug for BNCT. An extensive analysis of BPO4 NP biocompatibility was performed using both mature blood cells (erythrocytes, neutrophils and platelets) and a model of hematopoietic progenitor cells. A time-and concentration-dependent cytotoxicity study was performed on neoplastic coloncarcinoma and osteosarcoma cell lines. BPO4 functionalization with folic acid, introduced to improve the uptake by tumor cells, appeared to effectively limit the unwanted effects of NPs on the analyzed blood components.From the Clinical Editor: Boron neutron capture therapy (BNCT) is a radiotherapy treatment modality based on the accumulation of a B-10-containing drug and subsequent irradiation with low energy neutrons, inducing the decay of B-10 to Li-7 and an a particle, causing neoplastic cell death. This team of authors reports on a folic acid functionalized BPO4 nanoparticle with improved characteristics compared with conventional BNCT approaches, as demonstrated in tumor cell lines, and hopefully to be followed by translational human studies. (C) 2014 Elsevier Inc. All rights reserved.