Vitamin A-responsive panocular xerophthalmia in a healthy adult.
Vitamin A-responsive panocular xerophthalmia in a healthy adult.
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健康成人的维生素 A 反应性全眼干眼症。
DOI：
10.1001/archopht.1978.03910060264016
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发表时间：
1978
影响因子：
--
通讯作者：
W. Green
中科院分区：
文献类型：
--
作者：
A. Sommer;S. Tjakrasudjatma;E. Djunaedi;W. Green
一名不寻常的典型干眼症病例发生在一名原本健康、营养良好的 25 岁女性身上。她有明显的结膜和角膜干燥症，包括早期基质水肿、视网膜色素上皮不断发生的色素改变，以及与视网膜病变分布平行的视野明显收缩。口服维生素 A 治疗两周内，结膜、角膜和视野的异常现象消失，1 1/2 个月后，许多视网膜病变也消失。该病例支持单独的维生素 A 缺乏在角膜干燥症和“眼底干燥症”病因中的首要地位；表明基质水肿是角膜受累的重要早期组成部分；并将眼底镜异常定位于视网膜色素上皮。
An unusual case of classical xerophthalmia occurred in an otherwise healthy, well-nourished, 25-year-old woman. She had marked conjunctival and corneal xerosis, including early stromal edema, evolving pigmentary alterations of the retinal pigment epithelium, and notable constriction of her visual fields, which paralleled the distribution of the retinal lesions. Abnormalities of the conjunctiva, cornea, and visual fields disappeared within two weeks of oral vitamin A therapy, and 1 1/2 months later, many of the retinal lesions cleared as well. This case supports the primacy of isolated vitamin A deficiency in the etiology of corneal xerosis and "fundus xerophthalmicus"; demonstrates that stromal edema is an important early component of corneal involvement; and localizes the funduscopic abnormalities to the retinal pigment epithelium.