Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse
Cochlin deposits in the trabecular meshwork of the glaucomatous DBA/2J mouse
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DOI：
10.1016/j.exer.2005.01.028
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发表时间：
2005-05-01
影响因子：
3.4
通讯作者：
Crabb, JW
中科院分区：
文献类型：
--
作者：
Bhattacharya, SK;Annangudi, SP;Crabb, JW
Cochlin deposits were observed in the trabecular meshwork (TM) of 8-month-old glaucomatous DBA/2J mice, coincident with the reported onset of increased intraocular pressure and optic nerve damage. An age-dependent increase in cochlin was observed up to 10 months of age and was paralleled by a decrease in type II collagen. Similar expression patterns exist in the TM of humans with primary open-angle glaucoma. Cochlin deposits, absent in non-glaucomatous mouse and human TM, may disrupt the TM extracellular matrix and obstruct aqueous humor circulation. Studies of DBA/2J mice offer promise for understanding the role cochlin may play in glaucoma. (c) 2005 Elsevier Ltd. All rights reserved.
