3D printed contact lenses for the management of color blindness
3D printed contact lenses for the management of color blindness
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DOI：
10.1016/j.addma.2021.102464
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发表时间：
2022-01-01
影响因子：
11
通讯作者：
Butt, Haider
中科院分区：
文献类型：
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作者：
Alam, Fahad;Salih, Ahmed E. E.;Butt, Haider
色盲或色觉缺陷(CVD)是一种先天性眼病，每12名男性和每200名女性中就有一人患有色盲。CVD目前还没有治愈方法；因此，患者选择可以增强他们颜色感知的可穿戴设备，如滤色眼镜和镜片。在这里，我们报告3D打印的隐形眼镜，以治疗色盲。我们利用原位合成的聚甲基丙烯酸羟乙酯(PHEMA)树脂和波长选择性过滤染料。与传统技术相比，3D打印具有制造容易和尺寸精度高的优势，使其成为制造定制色盲隐形眼镜的合适平台。此外，为了滤除不需要的波长，两种染料(即ATTO 565和488)被用于隐形眼镜的功能化。这些染料在550-580和480-500 nm波长范围内具有吸收带。有色隐形眼镜成功地阻挡了80%-90%的不想要的波长，CVD患者发现很难区分某些颜色的深浅。此外，3D打印水凝胶隐形眼镜没有观察到染料渗漏。用光学和物理化学方法对所制备的隐形眼镜进行了进一步的表征。使用石原测试对色盲患者进行了隐形眼镜测试，参与者的颜色感知得到了明显的增强。
Color blindness or color vision deficiency (CVD), a congenital ocular disorder, affects one in 12 males and one in 200 females. CVD currently has no cure; hence, patients opt for wearables that could enhance their color perception such as color filtering glasses and lenses. Herein, we report 3D printing of contact lenses for color blindness management. We utilized an in situ synthesized poly(2-hydroxyethyl methacrylate) (pHEMA) resin and wavelength selective filtering dyes. 3D printing has advantages as compared to conventional techniques due to its ease of manufacturing and high dimensional accuracy, making it a suitable platform for the fabrication of customized contact lenses for colorblindness. Moreover, to filter out the undesired wavelengths, two dyes (i.e., Atto 565 and 488) were utilized to functionalize in the contact lenses. These dyes have absorption bands in the range of 550-580 and 480-500 nm wavelength. The tinted contact lenses successfully blocked 80-90% of the undesired wavelengths, where CVD patients find difficulties in distinguishing shades of certain colors. Furthermore, no dye leakage was observed from the 3D printed hydrogel contact lenses. The fabricated contact lenses were further characterized by optical and physicochemical methods. Contact lenses were tested on colorblind patients using Ishihara test, and evident enhancements in the color perception of the participants were obtained.