Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats.
Inhibitory effect of the non-steroidal anti-inflammatory drug, indomethacin on the naturally occurring carcinogen, 1-hydroxyanthraquinone in male ACI/N rats.
复制标题
非甾体抗炎药吲哚美辛对雄性 ACI/N 大鼠中天然致癌物 1-羟基蒽醌的抑制作用。
作者：
Takuji Tanaka;T. Kojima;N. Yoshimi;S. Sugie;H. Mori
在雄性ACI/N大鼠中研究了非甾体抗炎药吲哚美辛对1-羟基蒽醌（1-HA）诱导的致癌作用的影响。动物喂食含有1.5%1-HA的饮食，同时给予吲哚美辛溶液（16 p. p.m.）48周的饮用水。大肠肿瘤的发病率（腺瘤和腺癌）和前胃在给予1-HA和吲哚美辛的大鼠中，（大肠肿瘤：0/14，0%;前胃肿瘤：2/14，14%）显著低于单独给予1-HA的大鼠大肠肿瘤12/27，44%;前胃肿瘤14/27，52%（分别为P = 0.002和P = 0.01）。在给予1-HA的大鼠中出现肝细胞腺瘤，而在给予1-HA和吲哚美辛的大鼠中没有出现肝肿瘤。在单独给予1-HA的大鼠（18/27，67%）和给予1-HA和吲哚美辛的大鼠（8/14，57%）中存在改变的肝细胞灶，但发现两组之间的发生率无显著差异。因此，非甾体抗炎药吲哚美辛显著抑制由天然存在的致癌物1-HA诱导的致癌作用。
The effect of the non-steroidal anti-inflammatory drug indomethacin on 1-hydroxyanthraquinone (1-HA)-induced carcinogenesis was investigated in male ACI/N rats. Animals were fed the diet containing 1.5% 1-HA and simultaneously given indomethacin solution (16 p.p.m.) as drinking water for 48 weeks. The incidences of large bowel neoplasms (adenomas and adenocarcinomas) and forestomach (papillomas) in rats given 1-HA and indomethacin (large intestinal tumors: 0/14, 0%; forestomach tumors: 2/14, 14%) were significantly lower than those in rats given 1-HA alone (large intestinal tumors: 12/27, 44%; forestomach tumors: 14/27, 52%) (P = 0.002 and P = 0.01 respectively). Liver cell adenomas were developed in a rat given 1-HA and no liver tumors in rats treated with 1-HA and indomethacin. Altered liver cell foci were present in rats given 1-HA alone (18/27, 67%) and those given 1-HA and indomethacin (8/14, 57%), but no significant difference in the incidence between the two groups was found. Untreated animals and rats given indomethacin alone had no neoplasms in the large bowel, forestomach and liver. Thus, the non-steroidal anti-inflammatory drug indomethacin significantly inhibited carcinogenesis induced by the naturally occurring carcinogen, 1-HA.